GdCl3 promoted synthesis of novel pyrimidine fused indazole derivatives and their anticancer activity

被引：24

作者：

Yakaiah, T. ^{[1
]}

Kurumurthy, C. ^{[1
]}

Lingaiah, B. P. V. ^{[1
]}

Narsaiah, B. ^{[1
]}

Pamanji, R. ^{[2
]}

Velatooru, L. R. ^{[2
]}

Rao, J. Venkateswara ^{[2
]}

Gururaj, S. ^{[4
]}

Parthasarathy, T. ^{[4
]}

Sridhar, B. ^{[3
]}

机构：

[1] Indian Inst Chem Technol, Fluoroorgan Div, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Toxicol, Hyderabad 500007, Andhra Pradesh, India

[3] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India

[4] Nizam Coll, Dept Chem, Hyderabad 500001, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 12期

关键词：

Indazoles; Aliphatic/aromatic aldehydes; Pyrimidines; Electron rich olefins; Anticancer activity; Rho-kinase (2F2U) protein; GENETIC ALGORITHM;

D O I：

10.1007/s00044-011-9962-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The three component Grieco condensation of indazoles, aliphatic/aromatic aldehydes, and electron rich olefins in the presence of GdCl3 resulted in a novel pyrimidine fused indazoles in single pot under mild conditions. Representative examples were screened for in vitro anti-cancer activity and some of the compounds exhibited promising cytotoxic activity against U937 cell lines in comparable with standard drug etoposide. The data were further compared with structure-based investigations using docking studies with the crystal structure of Rho-kinase (2F2U) protein. The fitness values estimated by genetic algorithm were found to have a good correlation with the experimental inhibitory potencies.

引用

页码：4261 / 4273

页数：13

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