GPR12 Selections of the metabolites from an endophytic Streptomyces sp Asociated with Cistanches deserticola

被引：29

作者：

Lin, Zhen-Jian ^{[1
]}

Lu, Xiao-Ming ^{[2
]}

Zhu, Tian-Jiao ^{[1
]}

Fang, Yu-Chun ^{[1
]}

Gu, Qian-Qun ^{[1
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Inst Marine Drugs & Food, Key Lab Marine Drugs, Chinese Minist Educ,Sch Med & Pharm, Qingdao 266003, Peoples R China

[2] E China Normal Univ, Shanghai Inst Brain Funct Genom, MOE STCSM, Key Lab Brain Funct Genom, Shanghai 200062, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 09期

关键词：

Cistanches deserticola; endophyte; Streptomyces; cyclopeptide; nucleoside; cAMP; GPR12;

D O I：

10.1007/s12272-001-1276-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y. C. Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.

引用

页码：1108 / 1114

页数：7

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