A Redundant Function for the N-Terminal Tail of Ndc80 in Kinetochore-Microtubule Interaction in Saccharomyces cerevisiae

被引：15

作者：

Demirel, Pinar B. ^{[1
]}

Keyes, Brice E. ^{[3
]}

Chaterjee, Mandovi ^{[2
]}

Remington, Courtney E. ^{[1
]}

Burke, Daniel J. ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22906 USA

[2] Univ Virginia, Sch Med, Dept Cell Biol, Charlottesville, VA 22906 USA

[3] Rockefeller Univ, Lab Mammalian Cell Biol & Dev, New York, NY 10021 USA

来源：

GENETICS | 2012年 / 192卷 / 02期

基金：

美国国家卫生研究院;

关键词：

SPINDLE CHECKPOINT; DASH COMPLEX; AURORA B; ATTACHMENT; YEAST; DAM1;

D O I：

10.1534/genetics.112.143818

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating a redundant function for the Ndc80 and Dam1 complexes in vivo.

引用

页码：753 / +

页数：9

共 21 条

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