Effects of orally administered bovine lactoperoxidase on dextran sulfate sodium-induced colitis in mice

被引：11
|
作者：
Shin, Kouichirou [1 ]
Horigome, Ayako [1 ]
Yamauchi, Koji [1 ]
Takase, Mitsunori [2 ]
Yaeshima, Tomoko [1 ]
Iwatsuki, Keiji [1 ]
机构：
[1] Morinaga Milk Ind Co Ltd, Inst Food Sci & Technol, Kanagawa 2288583, Japan
[2] Morinaga Milk Ind Co Ltd, Nutr Sci Inst, Kanagawa 2288583, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 07期
关键词：
lactoperoxidase; colitis; dextran sulphate sodium; interleukin-6;
D O I：
10.1271/bbb.70636
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening, and the histological score were significantly suppressed in mice orally administered LPO (62.5mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.
引用
收藏
页码：1932 / 1935
页数：4
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