Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention

被引：45

作者：

Romani, Massimo ^{[1
]}

Pistillo, Maria Pia ^{[1
]}

Banelli, Barbara ^{[1
]}

机构：

[1] IRCCS AOU San Martino IST, Lab Tumor Epigenet, I-16132 Genoa, Italy

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

FOLIC-ACID SUPPLEMENTATION; GENOMIC DNA METHYLATION; GENE-EXPRESSION; TRANSGENERATIONAL INHERITANCE; PROMOTER HYPERMETHYLATION; COLORECTAL-CANCER; BREAST-CANCER; LUNG-CANCER; HISTONE METHYLTRANSFERASES; MYELODYSPLASTIC SYNDROME;

D O I：

10.1155/2015/587983

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Epigenetics provides the key to transform the genetic information into phenotype and because of its reversibility it is considered an ideal target for therapeutic interventions. This paper reviews the basic mechanisms of epigenetic control: DNA methylation, histone modifications, chromatin remodeling, and ncRNA expression and their role in disease development. We describe also the influence of the environment, lifestyle, nutritional habits, and the psychological influence on epigenetic marks and how these factors are related to cancer and other diseases development. Finally we discuss the potential use of natural epigenetic modifiers in the chemoprevention of cancer to link together public health, environment, and lifestyle.

引用

页数：13

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