Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

被引：148

作者：

Correia, Sonia C. ^{[2
]}

Santos, Renato X. ^{[2
]}

Carvalho, Cristina ^{[2
]}

Cardoso, Susana ^{[2
]}

Candeias, Emanuel ^{[2
]}

Santos, Maria S. ^{[2
]}

Oliveira, Catarina R. ^{[3
]}

Moreira, Paula I. ^{[1
]}

机构：

[1] Univ Coimbra, Fac Med, Inst Physiol, Ctr Neurosci & Cell Biol, P-3000354 Coimbra, Portugal

[2] Univ Coimbra, Fac Sci & Technol, Dept Life Sci, P-3000354 Coimbra, Portugal

[3] Univ Coimbra, Inst Biochem, P-3000354 Coimbra, Portugal

来源：

BRAIN RESEARCH | 2012年 / 1441卷

关键词：

Alzheimer's disease; Diabetes; Cerebral glucose metabolism; Insulin signaling; Mitochondria; Oxidative stress; ISLET AMYLOID POLYPEPTIDE; GROWTH-FACTOR EXPRESSION; CYTOCHROME-C-OXIDASE; ALPHA-KETOGLUTARATE DEHYDROGENASE; HIPPOCAMPAL SYNAPTIC PLASTICITY; GLYCOGEN-SYNTHASE KINASE-3; GLYCATION END-PRODUCTS; CENTRAL-NERVOUS-SYSTEM; PANCREATIC BETA-CELLS; A-BETA;

D O I：

10.1016/j.brainres.2011.12.063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many epidemiological studies have shown that diabetes, particularly type 2 diabetes, significantly increases the risk to develop Alzheimer's disease. Both diseases share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and deposition of amyloidogenic proteins. It has been suggested that these two diseases disrupt common cellular and molecular pathways and each disease potentiates the progression of the other. This review discusses clinical and biochemical features shared by Alzheimer's disease and diabetes, giving special attention to the involvement of insulin signaling, glucose metabolism and mitochondria. Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：64 / 78

页数：15

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