Information feedback of 18F-FDG PET/CT computer imaging combined with tumor markers on recurrence and metastasis of non-small cell lung cancer

To investigate the diagnostic value or information feedback of tumor markers combined with F-18-FDG PET/CT computer imaging on recurrence and metastasis of non-small cell lung cancer (NSCLC). Methods: From January 2013 to December 2017, 95 NSCLC patients undergoing systemic F-18-FDG PET/CT computer imaging examination at the PET/CT computer imaging center of Mudanjiang Medical University had been enrolled. Typically, the interval between the completion of treatment and PET/CT computer imaging examination should be at least three months. Besides, all patients had undergone serum CEA monitoring before and after F-18-FDG PET/CT computer imaging, and 70 of them had received CYFRA21-1 test at the same time. Tumor markers were examined with PET/CT at intervals of less than one week, and all the feedback results were compared with clinical follow-up results or final pathology. Additionally, all the enrolled patients were followed up for 6-12 months. Results: The sensitivity, accuracy, specificity, positive predictive value and negative predictive value of F-18-FDGPET/CT information feedback in evaluating recurrence or metastasis after NSCLC treatment were superior to those of common tumor markers, and the differences were statistically significant (P < 0.05). Those of F-18-FDG PET/CT computer imaging combined with tumor marker examination for the recurrence and/or metastasis after NSCLC treatment were remarkably higher than those of either individual examination, and the accuracy difference of information feedback had significant statistical significance (P < 0.05). Clearly, the diagnosis using tumor markers was correlated with that by F-18-FDG PET/CT imaging, and the correlation coefficient was r = 0.63. Moreover, serum CEA was grouped at different levels, and the positive rate and accuracy of F-18-FDG PET/CT computer imaging diagnosis were increased with the increase in CEA level. 8 patients had received F-18-FDG PET/CT dual-phase examination, among them, 4 were diagnosed with recurrence or metastasis after MSCLC treatment, and all of them had been detected. (c) 2019 Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences.