Trifluoromethyl ketones: properties, preparation, and application

被引：152

作者：

Kelly, Christopher B. ^{[1
]}

Mercadante, Michael A. ^{[1
]}

Leadbeater, Nicholas E. ^{[1
,2
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

[2] Univ Connecticut, Ctr Hlth, Dept Community Med & Hlth Care, Farmington, CT 06030 USA

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 95期

基金：

美国国家科学基金会;

关键词：

ONE-POT SYNTHESIS; AEROBIC OXIDATIVE DECARBOXYLATION; CONVENIENT SYNTHETIC METHOD; ALPHA-HYDROXY-ACIDS; C BOND-CLEAVAGE; EFFICIENT SYNTHESIS; NUCLEOPHILIC TRIFLUOROMETHYLATION; ASYMMETRIC-SYNTHESIS; CARBOXYLIC-ACIDS; ETHYL 4,4,4-TRIFLUOROACETOACETATE;

D O I：

10.1039/c3cc46266h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trifluoromethyl ketones (TFMKs) are exceedingly valuable synthetic targets in their own right and as synthons in the construction of fluorinated pharmacons. This Feature Article provides an overview of the properties of TFMKs, an in-depth discussion of the methods available for their synthesis, and two illustrative examples of their application as key intermediates in medicinal chemistry.

引用

页码：11133 / 11148

页数：16

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