Comparative studies of modulatory effect to the function of rat peritoneal neutrophils treated with new quinolones

被引：20

作者：

Azuma, Y ^{[1
]}

Wang, PL ^{[1
]}

Shinohara, M ^{[1
]}

Okamura, M ^{[1
]}

Inui, Y ^{[1
]}

Suese, Y ^{[1
]}

Ohura, K ^{[1
]}

机构：

[1] Osaka Dent Univ, Dept Pharmacol, Hirakata, Osaka 5731121, Japan

来源：

IMMUNOLOGY LETTERS | 1999年 / 69卷 / 03期

关键词：

new quinolones; neutrophil; adhesion; phagocytosis; superoxide anion; hydrogen peroxide;

D O I：

10.1016/S0165-2478(99)00112-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Some of the immunological effects of a variety of new quinolones on adhesion, phagocytosis, and production of reactive oxygen intermediators in neutrophils were studied. Ofloxacin, lomefloxacin, fleroxacin, and levofloxacin potentiated the phagocytosis of Escherichia coli in neutrophils. Moreover, lomefloxacin, and sparfloxacin significantly potentiated adhesion of neutrophils. In contrast, tosufloxacin was effective in significantly and persistently potentiating the production of superoxide anion, whereas the other agents markedly inhibited such production. Furthermore, tosufloxacin was effective in significantly potentiating the production of hydrogen peroxide, whereas sparfloxacin markedly inhibited such production. These results suggest that the new quinolones at a therapeutic concentration may affect functions such as phagocytosis, and production of superoxide anion in neutrophils. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：321 / 327

页数：7

共 23 条

[1] Effect of pyridone carboxylic acid anti-microbials on the generation of reactive oxygen species in vitro [J].

Akamatsu, H ;

Niwa, Y ;

Sasaki, H ;

Matoba, Y ;

Asada, Y ;

Horio, T .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1996, 24 (04) :345-351

[2]

AZUMA Y, 1999, IN PRESS GEN PHARM

[3]

BOOGAERTS MA, 1986, INFECTION S4, V14, P258

[4] PHARMACOKINETICS AND PHARMACODYNAMICS OF NEUTROPHIL-ASSOCIATED CIPROFLOXACIN IN HUMANS [J].

CAPECCHI, PL ;

BLARDI, P ;

DELALLA, A ;

CECCATELLI, L ;

VOLPI, L ;

PASINI, FL ;

DIPERRI, T .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 57 (04) :446-454

[5] INFLUENCE OF OFLOXACIN AND PEFLOXACIN ON HUMAN-LYMPHOCYTE IMMUNOGLOBULIN SECRETION AND ON POLYMORPHONUCLEAR LEUKOCYTE SUPEROXIDE ANION PRODUCTION [J].

FANTONI, M ;

TAMBURRINI, E ;

PALLAVICINI, F ;

ANTINORI, A ;

NERVO, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 (02) :193-196

[6] UPTAKE AND INTRACELLULAR ACTIVITY OF SPARFLOXACIN IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES AND TISSUE-CULTURE CELLS [J].

GARCIA, I ;

PASCUAL, A ;

GUZMAN, MC ;

PEREA, EJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (05) :1053-1056

[7] ROLE OF PROTEIN-KINASES IN STIMULATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE OXIDATIVE-METABOLISM BY VARIOUS AGONISTS - DIFFERENTIAL-EFFECTS OF A NOVEL PROTEIN-KINASE INHIBITOR [J].

GERARD, C ;

MCPHAIL, LC ;

MARFAT, A ;

STIMLERGERARD, NP ;

BASS, DA ;

MCCALL, CE .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (01) :61-65

[8] INFLUENCE OF PENTOXIFYLLINE AND ITS DERIVATIVES ON ANTIBIOTIC UPTAKE AND SUPEROXIDE GENERATION BY HUMAN PHAGOCYTIC-CELLS [J].

HAND, WL ;

HAND, DL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (07) :1574-1579

[9] INTERACTIONS OF DIRITHROMYCIN WITH HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

HAND, WL ;

HAND, DL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (12) :2557-2562

[10]

HORWITZ MA, 1982, REV INFECT DIS, V4, P104

← 1 2 3 →