Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

被引：65

作者：

Galano, Jean-Marie ^{[1
]}

Mas, Emilie ^{[2
,3
]}

Barden, Anne ^{[2
,3
]}

Mori, Trevor A. ^{[2
,3
]}

Signorini, Cinzia ^{[4
]}

De Felice, Claudio ^{[5
]}

Barrett, Aaron ^{[6
]}

Opere, Catherine ^{[6
]}

Pinot, Edith ^{[1
]}

Schwedhelm, Edzard ^{[7
]}

Benndorf, Ralf ^{[9
]}

Roy, Jerome ^{[8
]}

Le Guennec, Jean-Yves ^{[8
]}

Oger, Camille ^{[1
]}

Durand, Thierry ^{[1
]}

机构：

[1] Univ Montpellier I & II, ENSCM, Fac Pharm, CNRS,UMR 5247,Inst Biomol Max Mousseron, Montpellier, France

[2] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia

[3] Cardiovasc Res Ctr, Perth, WA, Australia

[4] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy

[5] Azienda Osped Univ Senese, Univ Hosp, Neonatal Intens Care Unit, Siena, Italy

[6] Creighton Univ, Med Ctr, Sch Pharm & Hlth Profess, Dept Pharm Sci, Omaha, NE 68178 USA

[7] Univ Med Ctr Hamburg Eppendorf, Inst Clin Pharmacol & Toxicol, Hamburg, Germany

[8] Univ Montpellier I & II, Inserm Physiol & Med Expt Coeur & Muscles U1046, Montpellier, France

[9] Univ Wurzburg, Inst Anat & Cell Biol, D-97070 Wurzburg, Germany

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2013年 / 107卷

关键词：

PUFAs; Metabolites; Isoprostanes; Neuroprostanes; Biomarkers; Bioactive lipids; THROMBOXANE A(2) RECEPTOR; INTERNAL MAMMARY ARTERY; FORMED IN-VIVO; DOCOSAHEXAENOIC ACID; LIPID-PEROXIDATION; RETT-SYNDROME; PROSTANOIDS F2-ISOPROSTANES; VASOCONSTRICTOR RESPONSES; CEREBROSPINAL-FLUID; ENDOTHELIAL-CELLS;

D O I：

10.1016/j.prostaglandins.2013.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：95 / 102

页数：8

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