Occurrence of etravirine/rilpivirine-specific resistance mutations selected by efavirenz and nevirapine in Kenyan patients with non-B HIV-1 subtypes failing antiretroviral therapy

被引：9

作者：

Crawford, Keith W. ^{[1
,2
]}

Njeru, Dorothy ^{[3
]}

Maswai, Jonah ^{[4
]}

Omondi, Milton ^{[4
]}

Apollo, Duncan ^{[3
]}

Kimetto, Jane ^{[4
]}

Gitonga, Lawrence ^{[3
]}

Munyao, James ^{[4
]}

Langat, Raphael ^{[4
]}

Aoko, Appolonia ^{[4
]}

Tarus, Jemutai ^{[4
]}

Khamadi, Samoel ^{[5
]}

Hamm, Tiffany E. ^{[1
,2
]}

机构：

[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Global Hlth Programs, Silver Spring, MD USA

[2] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA

[3] USAM RU K, KDF, Nairobi, Kenya

[4] USAMRU K, Kenya Med Res Inst KEMRI, Walter Reed Program, SRV, Kerich, Kenya

[5] Southern Highlands Walter Reed Program, Mbeya, Tanzania

来源：

AIDS | 2014年 / 28卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; DRUG-RESISTANCE; INTERPRETATION ALGORITHMS; REVERSE-TRANSCRIPTASE; GENOTYPIC RESISTANCE; PROTEASE; INHIBITORS; DIVERSITY; PATTERNS; FAILURE;

D O I：

10.1097/QAD.0000000000000140

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Resistance to efavirenz and nevirapine has not been associated with mutations at position 138 of reverse transcriptase. In an evaluation of virologic suppression rates in PEPFAR (President's Emergency Plan For AIDS Relief) clinics in Kenya among patients on first-line therapy (RV288), 63% (617/975) of randomly selected patients on antiretroviral therapy were suppressed (HIV RNA<400copies/ml). Among those with non-nucleoside reverse transcriptase inhibitor resistance (n=101), 14 (13.8%) had substitutions at 138 (A, G, K or Q), mutations selected only by etravirine and rilpivirine in subtype B viruses. All 14 patients received efavirenz or nevirapine, not etravirine or rilpivirine, and were predominantly subtype A1. This may be the first report of efavirenz and nevirapine selecting these mutations in these subtypes.

引用

页码：442 / 445

页数：4

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