Effects and moderators of exercise on quality of life and physical function in patients with cancer: An individual patient data meta-analysis of 34 RCTs

被引：397

作者：

Buffart, Laurien M. ^{[1
,10
,14
,16
,18
,29
]}

Kalter, Joeri ^{[2
,5
,6
]}

Sweegers, Maike G. ^{[4
,20
,27
,35
]}

Courneya, Kerry S. ^{[18
]}

Newton, Robert U. ^{[5
,9
,15
,22
,30
]}

Aaronson, Neil K. ^{[2
,8
,25
]}

Jacobsen, Paul B. ^{[10
,17
,21
,26
,31
,41
]}

May, Anne M. ^{[3
,11
,23
]}

Galvao, Daniel A. ^{[1
,8
,13
,14
,20
]}

Chinapaw, Mai J. ^{[2
,4
,5
,15
,30
]}

Steindorf, Karen ^{[3
]}

Irwin, Melinda L. ^{[27
,28
]}

Stuiver, Martijn M. ^{[18
,38
,39
]}

Hayes, Sandi ^{[2
,14
,33
]}

Griffith, Kathleen A. ^{[1
,6
,20
]}

Lucia, Alejandro ^{[5
,14
,15
,18
,22
]}

Mesters, Ilse ^{[21
,30
,31
]}

van Weert, Ellen ^{[2
,23
,32
]}

Knoop, Hans ^{[1
,7
,37
]}

Goedendorp, Martine M. ^{[2
,4
,5
,7
,11
,25
,44
]}

Mutrie, Nanette ^{[21
,24
,33
,40
]}

Daley, Amanda J. ^{[22
,27
]}

McConnachie, Alex

Bohus, Martin ^{[25
,34
]}

Thorsen, Lene

Schulz, Karl-Heinz ^{[8
,19
,20
]}

Short, Camille E. ^{[3
,12
]}

James, Erica L. ^{[7
,11
,26
]}

Plotnikoff, Ron C. ^{[14
,23
,34
]}

Arbane, Gill ^{[10
,11
,12
,19
,21
]}

Schmidt, Martina E. ^{[8
,9
,13
]}

Potthoff, Karin ^{[20
]}

van Beurden, Marc

Oldenburg, Hester S. ^{[8
,10
,19
,36
]}

Sonke, Gabe S. ^{[3
,21
]}

van Harten, Wim H. ^{[22
]}

Garrod, Rachel ^{[19
,20
]}

Schmitz, Kathryn H. ^{[10
,15
]}

Winters-Stone, Kerri M. ^{[13
,43
]}

Velthuis, Miranda J. ^{[13
,22
,23
]}

Taaffe, Dennis R. ^{[17
,23
,40
]}

van Mechelen, Willem ^{[4
,15
]}

Kersten, Marie Jose ^{[5
,8
,16
,20
,36
,39
]}

Nollet, Frans ^{[3
,42
]}

Wenzel, Jennifer ^{[13
,39
]}

Wiskemann, Joachim

Verdonck-de Leeuw, Irma M. ^{[6
,27
]}

Brug, Johannes ^{[11
]}

机构：

[1] Vrije Univ Amsterdam, Dept Epidemiol & Biostat, Med Ctr, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Dept Med Oncol, Med Ctr, Amsterdam, Netherlands

[3] Univ Alberta, Fac Phys Educ & Recreat, Edmonton, AB, Canada

[4] Edith Cowan Univ, Exercise Med Res Inst, Joondalup, WA, Australia

[5] Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands

[6] H Lee Moffitt Canc Ctr & Res Inst, Div Populat Sci, Tampa, FL USA

[7] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[8] Vrije Univ Amsterdam, Dept Publ & Occupat Hlth, Med Ctr, Amsterdam, Netherlands

[9] German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany

[10] Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[11] Yale Sch Publ Hlth, New Haven, CT USA

[12] Netherlands Canc Inst, Dept Physiotherapy, Amsterdam, Netherlands

[13] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Publ Hlth, Kelvin Grove, Qld, Australia

[14] Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA

[15] European Univ, Madrid, Spain

[16] Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands

[17] Univ Groningen, Univ Med Ctr Groningen, Ctr Rehabil, Groningen, Netherlands

[18] Acad Med Ctr, Dept Med Psychol, Amsterdam, Netherlands

[19] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Psychol, Groningen, Netherlands

[20] Univ Edinburgh, Act Hlth Res Ctr, Edinburgh, Midlothian, Scotland

[21] Univ Birmingham, Sch Hlth & Populat Sci, Coll Med & Dent Sci, Primary Care Clin Sci, Birmingham, W Midlands, England

[22] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland

[23] Heidelberg Univ, Inst Psychiat & Psychosomat Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany

[24] Univ Antwerp, Fac Hlth, Antwerp, Belgium

[25] Oslo Univ Hosp, Dept Oncol, Natl Advisory Unit Late Effects Canc, Oslo, Norway

[26] Univ Med Ctr Hamburg Eppendorf, Athleticum Competence Ctr Sports & Exercise Med &, Hamburg Eppendorf, Germany

[27] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Sch Med, Adelaide, SA, Australia

[28] Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW, Australia

[29] Univ Newcastle, Prior Res Ctr Phys Act & Nutr, Callaghan, NSW, Australia

[30] Guys & St Thomas NHS Fdn Trust, Lane Fox Resp Res Unit, London, England

[31] Natl Ctr Tumor Dis NCT, Dept Med Oncol, Heidelberg, Germany

[32] Univ Heidelberg Hosp, Heidelberg, Germany

[33] Natl Ctr Tumor Dis NCT, Dept Radiat Oncol, Heidelberg, Germany

[34] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Amsterdam, Netherlands

[35] Univ Twente, Enschede, Netherlands

[36] Kings Coll London, Dept Resp Med, London, England

[37] Coll Med, Penn State Hlth, Hershey, PA USA

[38] Inst Canc Res, Hershey, PA USA

[39] Oregon Hlth & Sci Univ, Portland, OR USA

[40] Acad Med Ctr, Dept Hematol, Amsterdam, Netherlands

[41] Johns Hopkins Sch Nursing, Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[42] Vrije Univ Amsterdam, Dept Otolaryngol Head & Neck Surg, Med Ctr, Amsterdam, Netherlands

[43] Vrije Univ Amsterdam, Dept Clin Psychol, Amsterdam, Netherlands

[44] Univ Amsterdam, Amsterdam Sch Commun Res ASCoR, Amsterdam, Netherlands

来源：

CANCER TREATMENT REVIEWS | 2017年 / 52卷

关键词：

Exercise; Quality of life; Physical function; Neoplasm; Individual patient data meta-analysis; RANDOMIZED CONTROLLED-TRIAL; AEROBIC EXERCISE; PROSTATE-CANCER; ADJUVANT CHEMOTHERAPY; PARTICIPANT DATA; HIGH-INTENSITY; CARDIORESPIRATORY FITNESS; ANDROGEN SUPPRESSION; RESISTANCE EXERCISE; ACTIVITY GUIDELINES;

D O I：

10.1016/j.ctrv.2016.11.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications. Principle investigators of all 69 eligible trials were requested to share IPD from their study. IPD from 34 randomised controlled trials (n = 4519 patients) that evaluated the effects of exercise compared to a usual care, wait-list or attention control group on QoL and PF in adult patients with cancer were retrieved and pooled. Linear mixed-effect models were used to evaluate the effects of the exercise on post-intervention outcome values (z-score) adjusting for baseline values. Moderator effects were studies by testing interactions. Exercise significantly improved QoL (beta = 0.15, 95%Cl = 0.10;0.20) and PF (beta = 0.18, 95%CI = 0.13;0.23). The effects were not moderated by demographic, clinical or exercise characteristics. Effects on QoL (beta(difference_in_effect) = 0.13, 95%CI = 0,03;0.22) and PF (beta(difrerence_in_effect) = 0.10, 95%CI = 0.01;0.20) were significantly larger for supervised than unsupervised interventions. In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment. Although effect sizes are small, there is consistent empirical evidence to support implementation of exercise as part of cancer care. (C) 2016 The Authors. Published by Elsevier Ltd.

引用

页码：91 / 104

页数：14

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