Flexural psoriasis induced by infliximab and adalimumab in a patient with Crohn's disease

被引：23
作者：
Avila Alvarez, A. [1 ]
Garcia-Alonso, L. [1 ]
Solar Boga, A. [1 ]
Garcia-Silva, J. [2 ]
机构：
[1] Complejo Hosp Univ A Coruna, Unidad Gastroenterol Pediat, Serv Pediat, La Coruna, Spain
[2] Complejo Hosp Univ A Coruna, Serv Dermatol, La Coruna, Spain
来源：
ANALES DE PEDIATRIA | 2009年 / 70卷 / 03期
关键词：
Infliximab; Adalimumab; Flexural psoriasis; Inflammatory bowel disease; TNF-ALPHA INHIBITORS; ADVERSE-REACTION; ANTIBODY; THERAPY; ARTHRITIS; LESIONS; ONSET;
D O I：
10.1016/j.anpedi.2008.11.013
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Anti-TNF drugs are used increasingly in several diseases with immune-mediated inflammation, not only in rheumatotogical conditions, but also in inflammatory bowel disease and psoriasis. Different side effects have been described over the last few years, including the development of psoriasis or psoriasiform exanthemas. These drugs began to be used in paediatrics during the 90's, therefore paediatricians need to be aware of the adverse effects that may occur. We describe here a flexural psoriasis induced by both infliximab and adalimumab in a paediatric patient with Crohn's Disease. To the best of our knowledge, this is the first reported paediatric case of psoriasis triggered by an anti-TNF drug, as well as the first case of psoriasis induced by adalimumab in patients with inflammatory bowel disease. (C) 2008 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：278 / 281
页数：4
相关论文
共 25 条
  • [1] Adams David R, 2006, J Drugs Dermatol, V5, P178
  • [2] Increase of peripheral CXCR3 positive T lymphocytes upon treatment of RA patients with TNF-α inhibitors
    Aeberli, D
    Seitz, M
    Jüni, P
    Villiger, PM
    [J]. RHEUMATOLOGY, 2005, 44 (02) : 172 - 175
  • [3] Infliximab (REMICADE) therapy in the treatment of pediatric Crohn's disease
    Baldassano, R
    Braegger, CP
    Escher, JC
    DeWoody, K
    Hendricks, DF
    Keenan, GF
    Winter, HS
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2003, 98 (04) : 833 - 838
  • [4] Skin reaction to adalimumab
    Beuthien, W
    Mellinghoff, HU
    von Kempis, J
    [J]. ARTHRITIS AND RHEUMATISM, 2004, 50 (05): : 1690 - 1692
  • [5] Cohen JD, 2007, J RHEUMATOL, V34, P380
  • [6] Psoriasis and pustular dermatitis triggered by TNF-α inhibitors in patients with rheumatologic conditions
    de Gannes, Gillian C.
    Ghoreishi, Mchran
    Pope, Janet
    Russell, Anthony
    Bell, David
    Adams, Stewart
    Shojania, Kamran
    Martinka, Magdalena
    Dutz, Jan P.
    [J]. ARCHIVES OF DERMATOLOGY, 2007, 143 (02) : 223 - 231
  • [7] The yin and yang of TNF-α inhibition
    Fiorentino, David F.
    [J]. ARCHIVES OF DERMATOLOGY, 2007, 143 (02) : 233 - 236
  • [8] Psoriasis induced by infliximab:: a paradoxical event
    Gonzalez-Lopez, Marcos A.
    Blanco-Alonso, Ricardo
    Yanez-Diaz, Sonsoles
    Fernandez-Llaca, Hector
    [J]. MEDICINA CLINICA, 2006, 127 (08): : 316 - 316
  • [9] New onset or exacerbation of psoriatic skin lesions in patients with definite rheumatoid arthritis receiving tumour necrosis factor α antagonists
    Kary, S
    Worm, M
    Audring, H
    Huscher, D
    Renelt, M
    Sörensen, H
    Ständer, E
    Maass, U
    Lee, H
    Sterry, W
    Burmester, GR
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (03) : 405 - 407
  • [10] TNFα therapy in psoriatic arthritis and psoriasis
    Mease, P
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 (07) : 755 - 758
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