3D Scaffolds to Study Basic Cell Biology

被引：108

作者：

Hippler, Marc ^{[1
,2
]}

Lemma, Enrico Domenico ^{[1
]}

Bertels, Sarah ^{[1
,3
]}

Blasco, Eva ^{[4
]}

Barner-Kowollik, Christopher ^{[4
,5
]}

Wegener, Martin ^{[2
,6
]}

Bastmeyer, Martin ^{[1
,3
]}

机构：

[1] Karlsruhe Inst Technol, Zool Inst, Fritz Haber Weg 4, D-76131 Karlsruhe, Germany

[2] Karlsruhe Inst Technol, Inst Appl Phys, Wolfgang Gaede Str 1, D-76131 Karlsruhe, Germany

[3] Karlsruhe Inst Technol, Inst Funct Interfaces, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

[4] Karlsruhe Inst Technol, Inst Tech Chem & Polymer Chem, Macromol Architectures, Engesserstr 18, D-76128 Karlsruhe, Germany

[5] Queensland Univ Technol, Sch Chem Phys & Mech Engn, 2 George St, Brisbane, Qld 4000, Australia

[6] Karlsruhe Inst Technol, Inst Nanotechnol, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

来源：

ADVANCED MATERIALS | 2019年 / 31卷 / 26期

基金：

澳大利亚研究理事会;

关键词：

3D scaffolds; cell adhesion; cell mechanics; direct laser writing; tissue engineering; 2-PHOTON POLYMERIZATION; MECHANICAL-PROPERTIES; HYDROGELS; FABRICATION; NANOSCALE; MIGRATION; MATRIX;

D O I：

10.1002/adma.201808110

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mimicking the properties of the extracellular matrix is crucial for developing in vitro models of the physiological microenvironment of living cells. Among other techniques, 3D direct laser writing (DLW) has emerged as a promising technology for realizing tailored 3D scaffolds for cell biology studies. Here, results based on DLW addressing basic biological issues, e.g., cell-force measurements and selective 3D cell spreading on functionalized structures are reviewed. Continuous future progress in DLW materials engineering and innovative approaches for scaffold fabrication will enable further applications of DLW in applied biomedical research and tissue engineering.

引用

页数：5

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