SOCS regulation of the JAK/STAT signalling pathway

被引：550
作者：
Croker, Ben A. [1 ]
Kiu, Hiu [1 ]
Nicholson, Sandra E. [1 ]
机构：
[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2008年 / 19卷 / 04期
基金：
美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
Cytokine signalling; SOCS; SH2; domain; SOCS box; Inflammation;
D O I：
10.1016/j.semcdb.2008.07.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and the complexities of the mouse models that have underpinned our current understanding of SOCS biology. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：414 / 422
页数：9
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