Molecular Genetics of Dyslexia: An Overview

被引:92
|
作者
Carrion-Castillo, Amaia [1 ]
Franke, Barbara [2 ]
Fisher, Simon E. [1 ,2 ]
机构
[1] Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands
关键词
molecular genetics; dyslexia; review; QUANTITATIVE-TRAIT LOCUS; ALTERED BRAIN ACTIVATION; DEVELOPMENTAL DYSLEXIA; SUSCEPTIBILITY LOCUS; READING-DISABILITY; NEURONAL MIGRATION; CANDIDATE GENES; ASSOCIATION ANALYSIS; SPELLING DISABILITY; LINKAGE ANALYSES;
D O I
10.1002/dys.1464
中图分类号
G76 [特殊教育];
学科分类号
040109 ;
摘要
Dyslexia is a highly heritable learning disorder with a complex underlying genetic architecture. Over the past decade, researchers have pinpointed a number of candidate genes that may contribute to dyslexia susceptibility. Here, we provide an overview of the state of the art, describing how studies have moved from mapping potential risk loci, through identification of associated gene variants, to characterization of gene function in cellular and animal model systems. Work thus far has highlighted some intriguing mechanistic pathways, such as neuronal migration, axon guidance, and ciliary biology, but it is clear that we still have much to learn about the molecular networks that are involved. We end the review by highlighting the past, present, and future contributions of the Dutch Dyslexia Programme to studies of genetic factors. In particular, we emphasize the importance of relating genetic information to intermediate neurobiological measures, as well as the value of incorporating longitudinal and developmental data into molecular designs. Copyright (c) 2013 John Wiley & Sons, Ltd.
引用
收藏
页码:214 / 240
页数:27
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