Assessment of endothelial and neurovascular function in human skin microcirculation

被引:256
作者
Roustit, Matthieu [1 ,2 ,3 ]
Cracowski, Jean-Luc [1 ,2 ,3 ]
机构
[1] Grenoble Univ Hosp, Clin Pharmacol Unit, Inserm CIC003, F-38043 Grenoble, France
[2] Inserm U1042, F-38043 Grenoble, France
[3] Univ Grenoble 1, F-38043 Grenoble, France
关键词
microcirculation; endothelium; laser Doppler; laser speckle; iontophoresis; local thermal hyperemia; post-occlusive hyperemia; microdialysis; skin; PRESSURE-INDUCED VASODILATION; CUTANEOUS REACTIVE HYPEREMIA; SPONTANEOUSLY HYPERTENSIVE-RATS; PRIMARY RAYNAUDS-PHENOMENON; LASER-DOPPLER FLOWMETRY; AGED HUMAN SKIN; NITRIC-OXIDE; MICROVASCULAR FUNCTION; BLOOD-FLOW; DIABETES-MELLITUS;
D O I
10.1016/j.tips.2013.05.007
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Peripheral microvascular dysfunction has been described in many physiological and pathological conditions. Owing to its accessibility, the cutaneous microcirculation provides a unique index of microvascular function. Skin microvascular function has therefore been proposed as a prognostic marker or for evaluating the effect of drugs on the microcirculation. Various reactivity tests, coupled with techniques measuring skin blood flux, are used to non-invasively explore both endothelial and neurovascular microvascular functioning in humans. We review the advantages and limitations of the main reactivity tests, including post-occlusive reactive hyperemia, local thermal hyperemia, pressure-induced vasodilation, and iontophoresis of vasodilators, combined with measurement techniques such as laser Doppler and laser speckle contrast imaging. Recent advances in our comprehension of the physiological pathways underlying these reactivity tests, as well as technological developments in microcirculation imaging, have provided reliable and reproducible tools for studying the microcirculation.
引用
收藏
页码:373 / 384
页数:12
相关论文
共 104 条
[1]   Comparative reproducibility of dermal microvascular blood flow changes in response to acetylcholine iontophoresis, hyperthermia and reactive hyperaemia [J].
Agarwal, Sharad C. ;
Allen, John ;
Murray, Alan ;
Purcell, Ian F. .
PHYSIOLOGICAL MEASUREMENT, 2010, 31 (01) :1-11
[2]   INVIVO EVALUATION OF SIGNAL PROCESSORS FOR LASER DOPPLER TISSUE FLOWMETERS [J].
AHN, H ;
JOHANSSON, K ;
LUNDGREN, O ;
NILSSON, GE .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1987, 25 (02) :207-211
[3]   Modulation of cytochrome-derived epoxyeicosatrienoic acids pathway: A promising pharmacological approach to prevent endothelial dysfunction in cardiovascular diseases? [J].
Bellien, Jeremy ;
Joannides, Robinson ;
Richard, Vincent ;
Thuillez, Christian .
PHARMACOLOGY & THERAPEUTICS, 2011, 131 (01) :1-17
[4]   Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients -: A monitoring test of endothelial dysfunction for clinical practice? [J].
Binggeli, C ;
Spieker, LE ;
Corti, R ;
Sudano, I ;
Stojanovic, V ;
Hayoz, D ;
Lüscher, TF ;
Noll, G .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (01) :71-77
[5]   Oral sildenafil increases skin hyperaemia induced by iontophoresis of sodium nitroprusside in healthy volunteers [J].
Blaise, S. ;
Hellmann, M. ;
Roustit, M. ;
Isnard, S. ;
Cracowski, J. L. .
BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (05) :1128-1134
[6]   The cutaneous microcirculation: Ultrastructure and microanatomical organization [J].
Braverman, IM .
MICROCIRCULATION, 1997, 4 (03) :329-340
[7]   Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging [J].
Briers, JD .
PHYSIOLOGICAL MEASUREMENT, 2001, 22 (04) :R35-R66
[8]   Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin [J].
Bruning, Rebecca S. ;
Santhanam, Lakshmi ;
Stanhewicz, Anna E. ;
Smith, Caroline J. ;
Berkowitz, Dan E. ;
Kenney, W. Larry ;
Holowatz, Lacy A. .
JOURNAL OF APPLIED PHYSIOLOGY, 2012, 112 (12) :2019-2026
[9]   KCa channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin [J].
Brunt, Vienna E. ;
Minson, Christopher T. .
JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (15) :3523-3534
[10]   Cutaneous thermal hyperemia: more than skin deep [J].
Brunt, Vienna E. ;
Minson, Christopher T. .
JOURNAL OF APPLIED PHYSIOLOGY, 2011, 111 (01) :5-7