Toward a Reconceptualization of Stem Cells from Cellular Plasticity

被引：5

作者：

Liu, Tao ^{[1
]}

Chen, Li ^{[2
]}

Zhao, Zhongjian ^{[3
]}

Zhang, Shichang ^{[3
]}

机构：

[1] Chinese PLA, Dept Infect Dis, Navy Hosp 971, Qingdao, Shandong, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Obstet, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Lab Med, Nanjing 210029, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF STEM CELLS | 2019年 / 12卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Stem cells; Plasticity; Differentiation; Dedifferentiation; Transdifferentiation; STEM/PROGENITOR CELLS; PROGENITOR CELLS; ADULT LIVER; HEPATOCYTES; BILIARY; REGENERATION; MECHANISMS; DISEASE; RATHER; REPAIR;

D O I：

10.15283/ijsc18096

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The slow progress in clinical applications of stem cells and the bewildering mechanisms involved have puzzled many researchers. Recently, the increasing evidences have indicated that cells have superior plasticity in vivo or in vitro, spontaneously or under extrinsic specific inducers. The concept of stem cells may be challenged, or even replaced by the concept of cell plasticity when cell reprogramming technology is progressing rapidly. The characteristics of stem cells are manifestations of cellular plasticity. Incorrect understanding of the concept of stem cells hinders the clinical application of so-called stem cells. Understanding cellular plasticity is important for understanding and treating disease. The above issues will be discussed in detail to prove the reconceptualization of stem cells from cellular plasticity.

引用

页码：1 / 7

页数：7

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