Use of genomic analysis of varicella-zoster virus to investigate suspected varicella-zoster transmission within a renal unit

Background: The source of hospital-acquired chickenpox infection may be presumed from a known exposure, but has not been previously proven using genomic analysis. Objective: Investigation of suspected VZV transmission was done using single nucleotide polymorphism genomic analysis. Study design: Comparison was made of viral isolates from two patients with chickenpox on the same ward who were not known to have had direct contact. Results: An identical genotype in the variable R1 region of the VZV was isolated from the two patients. Conclusion: Inapparent hospital-acquired transmission was the most likely route of infection. (C) 2006 Elsevier B.V. All rights reserved.