Spatiotemporal Evolution of the Primary Glioblastoma Genome

被引：252

作者：

Kim, Jinkuk ^{[1
,3
]}

Lee, In-Hee ^{[1
,2
]}

Cho, Hee Jin ^{[1
,4
]}

Park, Chul-Kee ^{[5
]}

Jung, Yang-Soon ^{[6
]}

Kim, Yanghee ^{[1
]}

Nam, So Hee ^{[1
]}

Kim, Byung Sup ^{[6
]}

Johnson, Mark D. ^{[8
]}

Kong, Doo-Sik ^{[6
]}

Seol, Ho Jun ^{[6
]}

Lee, Jung-Il ^{[6
]}

Joo, Kyeung Min ^{[1
,4
,7
]}

Yoon, Yeup ^{[1
,4
]}

Park, Woong-Yang ^{[1
,2
,4
]}

Lee, Jeongwu ^{[11
]}

Park, Peter J. ^{[9
,10
]}

Nam, Do-Hyun ^{[1
,4
,6
]}

机构：

[1] Samsung Med Ctr, Samsung Biomed Res Inst, Seoul 06351, South Korea

[2] Samsung Med Ctr, Samsung Genome Inst, Seoul 06351, South Korea

[3] Samsung Elect Co Ltd, Samsung Adv Inst Technol, Seoul 06351, South Korea

[4] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul 06351, South Korea

[5] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Neurosurg, Seoul 06351, South Korea

[6] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 06351, South Korea

[7] Sungkyunkwan Univ, Sch Med, Dept Anat & Cell Biol, Seoul 06351, South Korea

[8] Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA

[9] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA

[10] Harvard Univ, Sch Med, Dept Biomed Informat, Boston, MA 02115 USA

[11] Cleveland Clin, Lerner Res Inst, Dept Stem Cell Biol & Regenerat Med, Cleveland, OH 44195 USA

来源：

CANCER CELL | 2015年 / 28卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA; MALIGNANT GLIOMAS; MSH6; MUTATIONS; WHOLE-GENOME; TEMOZOLOMIDE; CANCER; GENES; IDH1; HETEROGENEITY; DNA;

D O I：

10.1016/j.ccell.2015.07.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor recurrence following treatment is the major cause of mortality for glioblastoma multiforme (GBM) patients. Thus, insights on the evolutionary process at recurrence are critical for improved patient care. Here, we describe our genomic analyses of the initial and recurrent tumor specimens from each of 38 GBM patients. A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor. In addition, in contrast to IDH1-mutated gliomas, IDH1-wild-type primary GBMs rarely developed hypermutation following temozolomide (TMZ) treatment, indicating low risk for TMZ-induced hypermutation for these tumors under the standard regimen.

引用

页码：318 / 328

页数：11

共 53 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2] Sequence analysis of mutations and translocations across breast cancer subtypes [J].

Banerji, Shantanu ;

Cibulskis, Kristian ;

Rangel-Escareno, Claudia ;

Brown, Kristin K. ;

Carter, Scott L. ;

Frederick, Abbie M. ;

Lawrence, Michael S. ;

Sivachenko, Andrey Y. ;

Sougnez, Carrie ;

Zou, Lihua ;

Cortes, Maria L. ;

Fernandez-Lopez, Juan C. ;

Peng, Shouyong ;

Ardlie, Kristin G. ;

Auclair, Daniel ;

Bautista-Pina, Veronica ;

Duke, Fujiko ;

Francis, Joshua ;

Jung, Joonil ;

Maffuz-Aziz, Antonio ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Pho, Nam H. ;

Quintanar-Jurado, Valeria ;

Ramos, Alex H. ;

Rebollar-Vega, Rosa ;

Rodriguez-Cuevas, Sergio ;

Romero-Cordoba, Sandra L. ;

Schumacher, Steven E. ;

Stransky, Nicolas ;

Thompson, Kristin M. ;

Uribe-Figueroa, Laura ;

Baselga, Jose ;

Beroukhim, Rameen ;

Polyak, Kornelia ;

Sgroi, Dennis C. ;

Richardson, Andrea L. ;

Jimenez-Sanchez, Gerardo ;

Lander, Eric S. ;

Gabriel, Stacey B. ;

Garraway, Levi A. ;

Golub, Todd R. ;

Melendez-Zajgla, Jorge ;

Toker, Alex ;

Getz, Gad ;

Hidalgo-Miranda, Alfredo ;

Meyerson, Matthew .

NATURE, 2012, 486 (7403) :405-409

[3]

BATRA SK, 1995, CELL GROWTH DIFFER, V6, P1251

[4]

Bodell W.J., 2003, CANC EPIDEMIOL BIOMA, V12, P545

[5] Evolutionary dynamics of cancer in response to targeted combination therapy [J].

Bozic, Ivana ;

Reiter, Johannes G. ;

Allen, Benjamin ;

Antal, Tibor ;

Chatterjee, Krishnendu ;

Shah, Preya ;

Moon, Yo Sup ;

Yaqubie, Amin ;

Kelly, Nicole ;

Le, Dung T. ;

Lipson, Evan J. ;

Chapman, Paul B. ;

Diaz, Luis A., Jr. ;

Vogelstein, Bert ;

Nowak, Martin A. .

ELIFE, 2013, 2

[6] The Somatic Genomic Landscape of Glioblastoma [J].

Brennan, Cameron W. ;

Verhaak, Roel G. W. ;

McKenna, Aaron ;

Campos, Benito ;

Noushmehr, Houtan ;

Salama, Sofie R. ;

Zheng, Siyuan ;

Chakravarty, Debyani ;

Sanborn, J. Zachary ;

Berman, Samuel H. ;

Beroukhim, Rameen ;

Bernard, Brady ;

Wu, Chang-Jiun ;

Genovese, Giannicola ;

Shmulevich, Ilya ;

Barnholtz-Sloan, Jill ;

Zou, Lihua ;

Vegesna, Rahulsimham ;

Shukla, Sachet A. ;

Ciriello, Giovanni ;

Yung, W. K. ;

Zhang, Wei ;

Sougnez, Carrie ;

Mikkelsen, Tom ;

Aldape, Kenneth ;

Bigner, Darell D. ;

Van Meir, Erwin G. ;

Prados, Michael ;

Sloan, Andrew ;

Black, Keith L. ;

Eschbacher, Jennifer ;

Finocchiaro, Gaetano ;

Friedman, William ;

Andrews, David W. ;

Guha, Abhijit ;

Iacocca, Mary ;

O'Neill, Brian P. ;

Foltz, Greg ;

Myers, Jerome ;

Weisenberger, Daniel J. ;

Penny, Robert ;

Kucherlapati, Raju ;

Perou, Charles M. ;

Hayes, D. Neil ;

Gibbs, Richard ;

Marra, Marco ;

Mills, Gordon B. ;

Lander, Eric ;

Spellman, Paul ;

Wilson, Richard .

CELL, 2013, 155 (02) :462-477

[7] Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment [J].

Cahill, Daniel P. ;

Levine, Kymberly K. ;

Betensky, Rebecca A. ;

Codd, Patrick J. ;

Romany, Candice A. ;

Reavie, Linsey B. ;

Batchelor, Tracy T. ;

Futreal, P. Andrew ;

Stratton, Michael R. ;

Curry, William T. ;

Iafrate, A. John ;

Louis, David N. .

CLINICAL CANCER RESEARCH, 2007, 13 (07) :2038-2045

[8] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].

Chin, L. ;

Meyerson, M. ;

Aldape, K. ;

Bigner, D. ;

Mikkelsen, T. ;

VandenBerg, S. ;

Kahn, A. ;

Penny, R. ;

Ferguson, M. L. ;

Gerhard, D. S. ;

Getz, G. ;

Brennan, C. ;

Taylor, B. S. ;

Winckler, W. ;

Park, P. ;

Ladanyi, M. ;

Hoadley, K. A. ;

Verhaak, R. G. W. ;

Hayes, D. N. ;

Spellman, Paul T. ;

Absher, D. ;

Weir, B. A. ;

Ding, L. ;

Wheeler, D. ;

Lawrence, M. S. ;

Cibulskis, K. ;

Mardis, E. ;

Zhang, Jinghui ;

Wilson, R. K. ;

Donehower, L. ;

Wheeler, D. A. ;

Purdom, E. ;

Wallis, J. ;

Laird, P. W. ;

Herman, J. G. ;

Schuebel, K. E. ;

Weisenberger, D. J. ;

Baylin, S. B. ;

Schultz, N. ;

Yao, Jun ;

Wiedemeyer, R. ;

Weinstein, J. ;

Sander, C. ;

Gibbs, R. A. ;

Gray, J. ;

Kucherlapati, R. ;

Lander, E. S. ;

Myers, R. M. ;

Perou, C. M. ;

McLendon, Roger .

NATURE, 2008, 455 (7216) :1061-1068

[9] Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples [J].

Cibulskis, Kristian ;

Lawrence, Michael S. ;

Carter, Scott L. ;

Sivachenko, Andrey ;

Jaffe, David ;

Sougnez, Carrie ;

Gabriel, Stacey ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad .

NATURE BIOTECHNOLOGY, 2013, 31 (03) :213-219

[10] A neurocentric perspective on glioma invasion [J].

Cuddapah, Vishnu Anand ;

Robel, Stefanie ;

Watkins, Stacey ;

Sontheimer, Harald .

NATURE REVIEWS NEUROSCIENCE, 2014, 15 (07) :455-465

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