Human cathelicidin peptide LL37 binds telomeric G-quadruplex

被引：23

作者：

Jana, Jagannath ^{[1
]}

Kar, Rajiv Kumar ^{[1
]}

Ghosh, Anirban ^{[1
]}

Biswas, Atanu ^{[2
]}

Ghosh, Surajit ^{[2
]}

Bhunia, Anirban ^{[1
]}

Chatterjee, Subhrangsu ^{[1
]}

机构：

[1] Bose Inst, Dept Biophys, Biomol NMR & Drug Design Lab, Kolkata, India

[2] CSIR Indian Inst Chem Biol, Div Chem, Kolkata, India

来源：

MOLECULAR BIOSYSTEMS | 2013年 / 9卷 / 07期

关键词：

HUMAN ANTIMICROBIAL PEPTIDE; LL-37; DNA;

D O I：

10.1039/c3mb70030e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stabilization of G-quadruplex inhibits the activity of the enzyme telomerase in cancer cells. We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures.

引用

页码：1833 / 1836

页数：4

共 19 条

[1] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
Ambrus, Attila
Chen, Ding
Dai, Jixun
Bialis, Tiffanie
Jones, Roger A.
Yang, Danzhou
[J]. NUCLEIC ACIDS RESEARCH, 2006, 34 (09) : 2723 - 2735
[2] LL-37 enhances adaptive antitumor immune response in a murine model when genetically fused with M-CSFRJ6-1 DNA vaccine
An, LL
Yang, YH
Ma, XT
Lin, YM
Li, G
Song, YH
Wu, KF
[J]. LEUKEMIA RESEARCH, 2005, 29 (05) : 535 - 543
[3] [Anonymous], 2011, DESM MOL DYN SYST VE
[4] Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputum
Bucki, R.
Byfield, F. J.
Janmey, P. A.
[J]. EUROPEAN RESPIRATORY JOURNAL, 2007, 29 (04) : 624 - 632
[5] LL-37 protects rats against lethal sepsis caused by gram-negative bacteria
Cirioni, O
Giacometti, A
Ghiselli, R
Bergnach, C
Orlando, F
Silvestri, C
Mocchegiani, F
Licci, A
Skerlavaj, B
Rocchi, M
Saba, V
Zanetti, M
Scalise, G
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (05) : 1672 - 1679
[6] LL-37, the only human member of the cathelicidin family of antimicrobial peptides
Durr, Ulrich H. N.
Sudheendra, U. S.
Ramamoorthy, Ayyalusamy
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (09): : 1408 - 1425
[7] Structure of Human Telomeric DNA in Crowded Solution
Heddi, Brahim
Anh Tuan Phan
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (25) : 9824 - 9833
[8] Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37
Henzler-Wildman, KA
Martinez, GV
Brown, MF
Ramamoorthy, A
[J]. BIOCHEMISTRY, 2004, 43 (26) : 8459 - 8469
[9] Apoptosis of airway epithelial cells - Human serum sensitive induction by the cathelicidin LL-37
Lau, YE
Bowdish, DME
Cosseau, C
Hancock, REW
Davidson, DJ
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2006, 34 (04) : 399 - 409
[10] Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity
Oren, Z
Lerman, JC
Gudmundsson, GH
Agerberth, B
Shai, Y
[J]. BIOCHEMICAL JOURNAL, 1999, 341 : 501 - 513

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