From COPD to Lung Cancer: Mechanisms Linking, Diagnosis, Treatment, and Prognosis

被引:58
作者
Qi, Chang [1 ]
Sun, Sheng-Wen [2 ]
Xiong, Xian-Zhi [1 ,3 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Resp & Crit Care Med,NHC Key Lab Pulm Dis, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Crit Care Med, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Resp & Crit Care Med, 1277 Jiefang Ave, Wuhan 430022, Peoples R China
关键词
COPD; lung cancer; endo-phenotyping of COPD; early diagnosis; biomarkers; immunotherapy; OBSTRUCTIVE PULMONARY-DISEASE; CHECKPOINT INHIBITOR EFFICACY; CIRCULATING TUMOR-CELLS; OXIDATIVE STRESS; INHALED CORTICOSTEROIDS; DNA-DAMAGE; HIGH-RISK; ASSOCIATION; EMPHYSEMA; SMOKING;
D O I
10.2147/COPD.S380732
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Many studies have proved that the pathogenesis of the chronic obstructive pulmonary disease (COPD) and lung cancer is related, and may cause and affect each other to a certain extent. In fact, the change of chronic airway obstruction will continue to have an impact on the screening, treatment, and prognosis of lung cancer.In this comprehensive review, we outlined the links and heterogeneity between COPD and lung cancer and finds that factors such as gene expression and genetic susceptibility, epigenetics, smoking, epithelial mesenchymal transformation (EMT), chronic inflammation, and oxidative stress injury may all play a role in the process. Although the relationship between these two diseases have been largely determined, the methods to prevent lung cancer in COPD patients are still limited. Early diagnosis is still the key to a better prognosis. Thus, it is necessary to establish more intuitive screening evaluation criteria and find suitable biomarkers for lung cancer screening in high-risk populations with COPD. Some studies have indicated that COPD may change the efficacy of anti-tumor therapy by affecting the response of lung cancer patients to immune checkpoint inhibitors (ICIs). And for lung cancer patients with COPD, the standardized management of COPD can improve the prognosis. The treatment of lung cancer patients with COPD is an individualized, comprehensive, and precise process. The development of new targets and new strategies of molecular targeted therapy may be the breakthrough for disease treatment in the future.
引用
收藏
页码:2603 / 2621
页数:19
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