The temperature field simulation of radiofrequency catheter-based renal sympathetic denervation for resistant hypertension

被引：8

作者：

Guo, Xuemei ^{[1
]}

Zhai, Fei ^{[1
]}

Nan, Qun ^{[1
]}

机构：

[1] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China

来源：

BIO-MEDICAL MATERIALS AND ENGINEERING | 2014年 / 24卷 / 01期

关键词：

Renal sympathetic denervation; resistant hypertension; finite element method; temperature distribution; radiofrequency ablation; BLOOD-PRESSURE; ABLATION;

D O I：

10.3233/BME-130813

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Renal sympathetic denervation (RSD) by the radiofrequency ablation was used to treat the resistant hypertension in clinic and has achieved curative effect. But the temperature distribution in the artery walls and the blood flow have not been investigated. Finite element method (FEM) based on Comsol Multiphysics 4.3a software was used to simulate the temperature distribution in the renal artery. The results of renal artery temperature distribution as well as blood flow effect on the temperature field were obtained, which demonstrated that the blood velocity is very crucial in the temperature distribution of blood vessel near antenna. When the speed of blood is 0.4 m/s, the highest temperature rise of arterial wall near the antenna is 8.882 degrees C (37 degrees C to 45.882 degrees C) and contralateral artery wall's highest temperature rise is about 5 degrees C (37 degrees C to 42 degrees C). This temperature value can damage renal sympathetic nerves to cure the resistant hypertension. Due to the blood flow, the temperature field stretches to the direction of blood flow. The temperature rise of blood is only in a small range (37 degrees C to 41 degrees C) at both ends of the antenna. The simulation of RSD by the radiofrequency ablation can give doctors a better scheme to avoid the vascular injury in different blood flow rates and radiofrequency voltages.

引用

页码：315 / 321

页数：7

共 15 条

[1]

[Anonymous], 2011, HYPERTENSION, V57, P911

[2] Thermal-electrical modeling for epicardial atrial radiofrequency ablation [J].

Berjano, EJ ;

Hornero, F .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2004, 51 (08) :1348-1357

[3] Distribution of SAR and temperature elevation induced in a phantom by a microwave cardiac ablation catheter [J].

Bernardi, P ;

Cavagnaro, M ;

Lin, JC ;

Pisa, S ;

Piuzzi, E .

IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, 2004, 52 (08) :1978-1986

[4]

Esler M., 1989, AM J HYPERTENS, V2, p140S

[5] Temperature-controlled and constant-power radio-frequency ablation: What affects lesion growth? [J].

Jain, MK ;

Wolf, PD .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1999, 46 (12) :1405-1412

[6] Device-Based Antihypertensive Therapy Therapeutic Modulation of the Autonomic Nervous System [J].

Krum, Henry ;

Sobotka, Paul ;

Mahfoud, Felix ;

Boehm, Michael ;

Esler, Murray ;

Schlaich, Markus .

CIRCULATION, 2011, 123 (02) :209-215

[7] Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study [J].

Krum, Henry ;

Schlaich, Markus ;

Whitbourn, Rob ;

Sobotka, Paul A. ;

Sadowski, Jerzy ;

Bartus, Krzysztof ;

Kapelak, Boguslaw ;

Walton, Anthony ;

Sievert, Horst ;

Thambar, Suku ;

Abraham, William T. ;

Esler, Murray .

LANCET, 2009, 373 (9671) :1275-1281

[8]

Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8

[9]

[李慧杰 Li Huijie], 2012, [第三军医大学学报, Journal of Third Military Medical University], V34, P434

[10]

Liu Jing, 2007, PRINCIPLE LOW TEMPER, P225

← 1 2 →