Diagnostic Accuracy of a Short Endoscopic Secretin Test in Patients With Cystic Fibrosis

被引：17

作者：

Engjom, Trond ^{[1
,2
]}

Erchinger, Friedemann ^{[1
,3
]}

Laerum, Birger Norderud ^{[4
,5
]}

Tjora, Erling ^{[5
,6
]}

Aksnes, Lage ^{[2
,5
,6
]}

Gilja, Odd Helge ^{[1
,7
]}

Dimcevski, Georg ^{[1
,2
]}

机构：

[1] Univ Bergen, Dept Clin Med, N-5020 Bergen, Norway

[2] Haukeland Hosp, Dept Med, N-5021 Bergen, Norway

[3] Voss Hosp, Dept Med, Voss, Norway

[4] Haukeland Hosp, Dept Thorac Med, N-5021 Bergen, Norway

[5] Univ Bergen, Dept Clin Sci, Bergen, Norway

[6] Haukeland Hosp, Dept Pediat, N-5021 Bergen, Norway

[7] Haukeland Hosp, Natl Ctr Ultrasound Gastroenterol, N-5021 Bergen, Norway

来源：

PANCREAS | 2015年 / 44卷 / 08期

关键词：

pancreas; cystic fibrosis; exocrine pancreatic function; secretin; endoscopy; EXOCRINE PANCREATIC-FUNCTION; FECAL ELASTASE-1; CFTR GENE; IDENTIFICATION; GUIDELINES; MUTATIONS; DISEASE; SUFFICIENCY; CROSSOVER; GENOTYPE;

D O I：

10.1097/MPA.0000000000000425

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: Short endoscopic secretin tests for exocrine pancreatic function are not properly evaluated in cystic fibrosis (CF). Methods: Patients with CF and healthy controls (HCs) underwent endoscopic collection of duodenal juice between 30 and 45 minutes after secretin stimulation. Duodenal juice was analyzed for HCO3- concentration and pancreatic enzyme activities. Stool was analyzed for fecal elastase. Results: Thirty-one patients with CF and 25 HCs were tested. Patients were classified as exocrine pancreatic sufficient (n = 13) or insufficient (n = 18). Both bicarbonate concentrations and enzyme activities in duodenal juice differentiated patients with CFI from patients with CFS and HC (P < 0.001). The population displays strong correlation between severe CF genotype in both alleles and pancreatic insufficient phenotype (P < 0.001). Conclusions: Pancreatic exocrine insufficient CF patients could be differentiated from exocrine sufficient patients and HCs using short endoscopic secretin test.

引用

页码：1266 / 1272

页数：7

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