New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

被引：13

作者：

Ogawa, Keiko ^{[1
]}

Nakamura, Seikou ^{[1
]}

Hosokawa, Kohei ^{[1
]}

Ishimaru, Hanako ^{[1
]}

Saito, Natsuki ^{[1
]}

Ryu, Kaori ^{[1
]}

Fujimuro, Masahiro ^{[1
]}

Nakashima, Souichi ^{[1
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Pharmacognosy, Yamashina Ku, Kyoto 6078412, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2018年 / 72卷 / 02期

关键词：

Nigella damascena; Ranunculaceae; Diterpene; Antiviral activity; HSV-1; MEDICINAL-PLANTS;

D O I：

10.1007/s11418-017-1166-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V-VIII were isolated. The structural determination of new compounds damasterpenes V-VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 mu M.

引用

页码：439 / 447

页数：9

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