Three clinical cases of nonrespiratory acidosis in kidney transplant recipients receiving anti-CMV therapy

被引：0

作者：

Kabat-Koperska, Joanna ^{[1
]}

Kedzierska, Karolina ^{[1
]}

Golembiewska, Edyta ^{[1
]}

Marchelek-Mysliwiec, Malgorzata ^{[1
]}

Dutkiewicz, Grazyna ^{[1
]}

Ciechanowski, Kazimierz ^{[1
]}

机构：

[1] Pomeranian Med Univ, Dept Nephrol & Transplantol, PL-70111 Szczecin, Poland

来源：

ANNALS OF TRANSPLANTATION | 2012年 / 17卷 / 02期

关键词：

kidney transplantation; cytomegalovirus; ganciclovir; valganciclovir; nonrespiratory acidosis; RENAL-ALLOGRAFT RECIPIENTS; CYTOMEGALOVIRUS-INFECTION; ANTIRETROVIRAL THERAPY; MITOCHONDRIAL-DNA; LACTIC-ACIDOSIS; DISEASE; IMPACT; SIROLIMUS; DEPLETION; FAILURE;

D O I：

暂无

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: To preserve kidney graft function it is necessary to use ganciclovir or valganciclovir as a therapy for fresh CMV infection or prophylaxis in high-risk kidney transplant recipients. Ganciclovir-induced lactic acidosis has thus far not been reported. Case Report: Three cases of nonrespiratory acidosis in kidney transplant recipients receiving ganciclovir or valganciclovir as anti-CMV therapy or prophylaxis are presented. Lactic acidosis developed in 2 patients, and the other patient had nonrespiratory acidosis of unknown origin. The possible mechanism of the development of lactic acidosis in presented cases is explored. Conclusions: The analysis of the described cases cannot eliminate the potential negative influence of anti-CMV therapy on acid-base equilibrium, especially with coexisting active viral infection.

引用

页码：135 / 140

页数：6

共 17 条

[1] Lactic acidosis in HIV infected patients: a systematic review of published cases
Arenas-Pinto, A
Grant, AD
Edwards, S
Weller, IVD
[J]. SEXUALLY TRANSMITTED INFECTIONS, 2003, 79 (04) : 340 - 344
[2] Einollahi B, 2009, ANN TRANSPL, V14, P32
[3] Immunosuppressive therapy and infection after kidney transplantation
Fortun, J.
Martin-Davila, P.
Pascual, J.
Cervera, C.
Moreno, A.
Gavalda, J.
Aguado, J. M.
Pereira, P.
Gurgui, M.
Carratala, J.
Fogueda, M.
Montejo, M.
Blasco, F.
Bou, G.
Torre-Cisneros, J.
[J]. TRANSPLANT INFECTIOUS DISEASE, 2010, 12 (05) : 397 - 405
[4] Mitochondrial cytopathies associated with HIV infection.
Gérard, Y
Melliez, H
Mouton, Y
Yazdanpanah, Y
[J]. REVUE NEUROLOGIQUE, 2006, 162 (01) : 62 - 70
[5] Sirolimus exposure during the early post-transplant period reduces the risk of CMV infection relative to tacrolimus in renal allograft recipients
Haririan, Abdoireza
Morawski, Katherina
West, Miguel S.
El-Amm, Jose M.
Doshi, Mona D.
Cincotta, Elizabeth
Alangaden, George J.
Chandrasekar, Pranatharthi
Gruber, Scott A.
[J]. CLINICAL TRANSPLANTATION, 2007, 21 (04) : 466 - 471
[6] Heering P, 1998, CLIN TRANSPLANT, V12, P465
[7] Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion
Herraiz, M
Beraza, N
Solano, A
Sangro, B
Montoya, J
Qian, C
Prieto, J
Bustos, M
[J]. HUMAN GENE THERAPY, 2003, 14 (05) : 463 - 472
[8] Asymptomatic cytomegalovirus infection is associated with increased risk of new-onset diabetes mellitus and impaired insulin release after renal transplantation
Hjelmesæth, J
Sagedal, S
Hartmann, A
Rollag, H
Egeland, T
Hagen, M
Nordal, KP
Jenssen, T
[J]. DIABETOLOGIA, 2004, 47 (09) : 1550 - 1556
[9] Increased incidence of cardiac complications in kidney transplant recipients with cytomegalovirus disease
Humar, A
Gillingham, K
Payne, WD
Sutherland, DER
Matas, AJ
[J]. TRANSPLANTATION, 2000, 70 (02) : 310 - 313
[10] Immunosuppressive Drugs in Kidney Transplantation Impact on Patient Survival, and Incidence of Cardiovascular Disease, Malignancy and Infection
Marcen, Roberto
[J]. DRUGS, 2009, 69 (16) : 2227 - 2243

← 1 2 →