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Chromatin states and nuclear organization in development - a view from the nuclear lamina
被引:51
|作者:
Mattout, Anna
[1
]
Cabianca, Daphne S.
[1
]
Gasser, Susan M.
[1
,2
]
机构:
[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
[2] Univ Basel, Fac Nat Sci, CH-4056 Basel, Switzerland
来源:
基金:
瑞士国家科学基金会;
关键词:
EMBRYONIC STEM-CELLS;
TOPOLOGICALLY ASSOCIATING DOMAINS;
DEACETYLASE;
3;
HDAC3;
B-TYPE LAMINS;
A-TYPE LAMINS;
CAENORHABDITIS-ELEGANS;
GENOME-WIDE;
BUDDING YEAST;
MEMBRANE PROTEIN;
MAMMALIAN-CELLS;
D O I:
10.1186/s13059-015-0747-5
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.
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页数:15
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