Chromatin states and nuclear organization in development - a view from the nuclear lamina

被引:51
|
作者
Mattout, Anna [1 ]
Cabianca, Daphne S. [1 ]
Gasser, Susan M. [1 ,2 ]
机构
[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
[2] Univ Basel, Fac Nat Sci, CH-4056 Basel, Switzerland
来源
GENOME BIOLOGY | 2015年 / 16卷
基金
瑞士国家科学基金会;
关键词
EMBRYONIC STEM-CELLS; TOPOLOGICALLY ASSOCIATING DOMAINS; DEACETYLASE; 3; HDAC3; B-TYPE LAMINS; A-TYPE LAMINS; CAENORHABDITIS-ELEGANS; GENOME-WIDE; BUDDING YEAST; MEMBRANE PROTEIN; MAMMALIAN-CELLS;
D O I
10.1186/s13059-015-0747-5
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.
引用
收藏
页数:15
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