Experimentally induced arousals do not elicit periodic leg motor activity during sleep in normal subjects

被引:14
作者
Ferri, Raffaele [1 ]
Manconi, Mauro [2 ]
Arico, Debora [1 ]
Punjabi, Naresh M. [3 ]
Zucconi, Marco [4 ,5 ]
机构
[1] Oasi Inst Res Mental Retardat & Brain Aging IRCCS, Dept Neurol IC, Troina, Italy
[2] Civ Hosp EOC Lugano, Sleep & Epilepsy Ctr, Neuroctr So Switzerland, Lugano, Switzerland
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[4] Univ Vita Salute San Raffaele, Sleep Disorders Ctr, Dept Neurol, Inst Sci,Inst & Osped San Raffaele, Milan, Italy
[5] Univ Vita Salute San Raffaele, Univ Osped San Raffaele, Inst & Osped San Raffaele, Milan, Italy
基金
美国国家卫生研究院;
关键词
Periodic leg movement during sleep; PLMS; Arousal; Autonomic activation; Sleep fragmentation; Heart rate variability; HEART-RATE-VARIABILITY; CYCLIC ALTERNATING PATTERN; DOPAMINE-AGONIST TREATMENT; LIMB MOVEMENTS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; CARDIAC ACTIVATION; RATE RESPONSE; RESTLESS; EEG;
D O I
10.1016/j.sleep.2012.09.021
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To evaluate whether eliciting repetitive cortical and autonomic arousals during sleep is able to induce the occurrence of periodic leg movements during sleep (PLMS). Methods: Fifteen normal subjects underwent one night of uninterrupted and two sequential nights of experimental sleep fragmentation achieved by auditory and mechanical stimuli eliciting frequent EEG arousals. Sleep was polygraphically recorded and subsequently used to determine the frequency of arousals and occurrence of leg movement (LM) activity during the first (baseline) and the second fragmentation night. Also, heart rate variability parameters were obtained to assess the autonomic changes induced by the stimulation. Results: Sleep fragmentation was associated with an increase in the arousal index, percentage of sleep stage 1, and frequency of stage shifts. In addition, there was a decrease in sleep latency and in percentage of slow-wave sleep. Moreover, a significant increase in heart rate variability and especially of its sympathetic component, was also found. In contrast, parameters of the leg movement activity showed no significant change following experimental sleep fragmentation. The lack of an increase in leg movement activity was also observed in one subject who demonstrated PLMS at baseline. Conclusions: Experimental sleep fragmentation is not associated with an increase in PLMS in normal young adults. (C) 2012 Elsevier B. V. All rights reserved.
引用
收藏
页码:85 / 90
页数:6
相关论文
共 38 条
[1]  
[Anonymous], 2005, INT CLASS SLEEP DIS
[2]   Undiagnosed individuals with first-degree relatives with restless legs syndrome have increased periodic limb movements [J].
Birinyi, Paul V. ;
Allen, Richard P. ;
Hening, Wayne ;
Washburn, Tinna ;
Lesage, Suzanne ;
Earley, Christopher J. .
SLEEP MEDICINE, 2006, 7 (06) :480-485
[3]   The impact of cyclic alternating pattern on heart rate variability during sleep in healthy young adults [J].
Ferini-Strambi, L ;
Bianchi, A ;
Zucconi, M ;
Oldani, A ;
Castronovo, V ;
Smirne, S .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (01) :99-101
[4]   Two legs, one heart, one sleeping brain [J].
Ferri, R .
SLEEP MEDICINE, 2006, 7 (03) :299-300
[5]   Computer-assisted detection of nocturnal leg motor activity in patients with restless legs syndrome and periodic leg movements during sleep [J].
Ferri, R ;
Zucconi, M ;
Manconi, M ;
Bruni, O ;
Miano, S ;
Plazzi, G ;
Ferini-Strambi, L .
SLEEP, 2005, 28 (08) :998-1004
[6]   Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep [J].
Ferri, R ;
Parrino, L ;
Smerieri, A ;
Terzano, MG ;
Elia, M ;
Musumeci, SA ;
Pettinato, S .
JOURNAL OF SLEEP RESEARCH, 2000, 9 (01) :13-18
[7]   Heart rate and spectral EEG changes accompanying periodic and isolated leg movements during sleep [J].
Ferri, Raffaele ;
Zucconi, Marco .
SLEEP, 2008, 31 (01) :16-17
[8]   Heart rate and spectral EEG changes accompanying periodic and non-periodic leg movements during sleep [J].
Ferri, Raffaele ;
Zucconi, Marco ;
Rundo, Francesco ;
Spruyt, Karen ;
Manconi, Mauro ;
Ferini-Strambi, Luigi .
CLINICAL NEUROPHYSIOLOGY, 2007, 118 (02) :438-448
[9]  
Ferri R, 2006, SLEEP, V29, P759
[10]   The time structure of leg movement activity during sleep: The theory behind the practice [J].
Ferri, Raffaele .
SLEEP MEDICINE, 2012, 13 (04) :433-441