Invasive Coinfection with Aspergillus and Mucor in a Patient with Acute Myeloid Leukemia

被引：21

作者：

Bergantim, Rui ^{[1
,2
]}

Rios, Elisabete ^{[3
]}

Trigo, Fernanda ^{[1
,2
]}

Guimaraes, Jose Eduardo ^{[1
,2
]}

机构：

[1] Sao Joao Hosp, Dept Clin Hematol, Oporto, Portugal

[2] Univ Porto, Fac Med, P-4100 Oporto, Portugal

[3] Sao Joao Hosp, Dept Anat Pathol, Oporto, Portugal

来源：

CLINICAL DRUG INVESTIGATION | 2013年 / 33卷

关键词：

SECONDARY ANTIFUNGAL PROPHYLAXIS; LIPOSOMAL AMPHOTERICIN-B; FUNGAL-INFECTIONS; HEMATOLOGICAL MALIGNANCIES; DISEASES; THERAPY; VORICONAZOLE; SOCIETY; TRIAL; RISK;

D O I：

10.1007/s40261-012-0022-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The authors report the case of a 58-year-old female patient with a life-threatening invasive fungal disease caused by a coinfection of Aspergillus and Mucor species that occurred during induction and consolidation chemotherapy for an acute myeloid leukemia. The disease was successfully treated with an aggressive therapeutic approach, which consisted of liposomal amphotericin B in combination with surgical exploration without compromising the treatment of her underlying disease. The case demonstrates the difficulties associated with establishing a diagnosis as well as the need for close observation to identify these infections, which are often misdiagnosed and only suspected late during the course of the disease. Doubts about the reliability of the diagnostic tools lead to uncertainties with regard to the choice of first-line drugs as well the selection of the most appropriate therapeutic strategy in hematologic patients.

引用

页码：S51 / S55

页数：5

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