Nectin-1 expression in cancer-associated fibroblasts is a predictor of poor prognosis for pancreatic ductal adenocarcinoma

被引：22

作者：

Yamada, Misuzu ^{[1
]}

Hirabayashi, Kenichi ^{[2
]}

Kawanishi, Aya ^{[3
]}

Hadano, Atsuko ^{[3
]}

Takanashi, Yumi ^{[2
]}

Izumi, Hideki ^{[1
]}

Kawaguchi, Yoshiaki ^{[3
]}

Mine, Tetsuya ^{[3
]}

Nakamura, Naoya ^{[2
]}

Nakagohri, Toshio ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Surg, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan

[2] Tokai Univ, Sch Med, Dept Pathol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan

[3] Tokai Univ, Sch Med, Dept Gastroenterol & Hepatol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan

来源：

SURGERY TODAY | 2018年 / 48卷 / 05期

关键词：

Pancreatic ductal adenocarcinoma; Nectin-1; Cell adhesion molecules; Cancer-associated fibroblast; Epithelial mesenchymal transition; EPITHELIAL-MESENCHYMAL TRANSITION; HEDGEHOG SIGNALING PATHWAY; PODOPLANIN EXPRESSION; THROMBOSPONDIN-1; EXPRESSION; TUMOR PROGRESSION; CARCINOMA; CELLS; GROWTH; INVASION; METASTASIS;

D O I：

10.1007/s00595-017-1618-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Nectin-1 is a cell adhesion molecule that regulates the formation of adherens junctions and tight junctions. We measured the expression of nectin-1 in cancer-associated fibroblasts (CAFs) in patients with pancreatic ductal adenocarcinoma (PDAC). Nectin-1 expression was measured via immunohistochemistry using tissue microarray blocks constructed from resected PDAC tissue from 258 patients. We screened for associations between nectin-1 expression and clinicopathological parameters. According to the percentage of CAFs stained, expression was classified as negative at <= 30% and positive at > 30%. Nectin-1 expression was confirmed in CAFs from 64 patients (24.8%), and was associated with lymph node metastasis (p = 0.016), advanced Union for International Cancer Control stage (p = 0.016), perineural invasion (p = 0.022), pancreatic head tumors (p = 0.023), and shorter overall survival (p = 0.003). Multivariate analysis revealed that nectin-1 expression in CAFs was an independent prognostic factor (p = 0.038). Diffuse nectin-1 expression in the CAFs of PDAC patients is associated with invasion, metastasis, and shorter survival.

引用

页码：510 / 516

页数：7