Analysis of structural requirements for thermo-adaptation from orthologs in microbial genomes

被引：5

作者：

Gao, Junxiang ^{[1
]}

Wang, Wei ^{[2
]}

机构：

[1] Huazhong Agr Univ, Coll Sci, Wuhan 430070, Peoples R China

[2] Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China

来源：

ANNALS OF MICROBIOLOGY | 2012年 / 62卷 / 04期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Thermal adaptation; Bacterial and archaeal genomes; Protein sequences; Optimal growth temperature; Cluster of orthologous groups of proteins; PROTEINS; EVOLUTION; ORIGIN;

D O I：

10.1007/s13213-012-0420-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A comprehensive survey was carried out to identify orthologs of proteins from 526 bacterial and archaeal genomes, with the aim of investigating the mechanism of thermal adaptation of protein sequences. A large number of orthologs were distributed only in thermophiles/hyperthermophiles (HT-only group) and mesophiles (M-only group). A significant relationship between amino acid composition and optimal growth temperature (OGT) was observed. There were significantly higher proportions of charged, basic and acidic amino acids in hyperthermophilic and thermophilic genomes than in mesophilic and psychrophilic genomes. The orthologs distributed in all the four temperature ranges (Top-90 group) were also investigated, and a similar correlation between amino acid composition and OGT was found. The composition of the cluster of orthologous groups of proteins (COG) of the above three groups was analyzed; the composition of 'information storage and processing' in the HT-only group and Top-90 groups was much higher than that of M-only group.

引用

页码：1635 / 1641

页数：7

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