The role of the insulin-like growth factor-I receptor in malignancy: An update

被引：54

作者：

Seccareccia, Erica ^{[1
]}

Brodt, Pnina ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H3A 1A1, Canada

[2] McGill Univ, Dept Surg, Montreal, PQ H3A 1A1, Canada

来源：

GROWTH HORMONE & IGF RESEARCH | 2012年 / 22卷 / 06期

关键词：

IGF; Cancer stem cell; EMT; Angiogenesis; Metastasis; Targeted therapy; CANCER STEM-CELLS; TO-MESENCHYMAL TRANSITION; NF-KAPPA-B; BREAST-CANCER; FACTOR EXPRESSION; MULTIPLE-MYELOMA; PROSTATE-CANCER; AUTOCRINE LOOP; MESSENGER-RNA; ANTISENSE RNA;

D O I：

10.1016/j.ghir.2012.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the past three decades, evidence has been accumulating that: the ICE-I receptor/ligand system plays an important role in malignant disease. This has led to a search for specific inhibitors of the ICF receptor for cancer therapy, revealing some predictable, but also unexpected challenges. Here we review recent data that highlight the essential role of the IGF axis in several important steps in cancer cell progression and metastasis and highlight cellular processes that have been the focus of much interest and new insight in recent years. Strategies used to target the IGF axis clinically are summarized and the obstacles encountered are discussed. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：193 / 199

页数：7

共 50 条

[41] Local expression of insulin-like growth factor-I affects angiogenesis in colorectal cancer
Bustin, SA
Dorudi, S
Phillips, SM
Feakins, RM
Jenkins, PJ
TUMOR BIOLOGY, 2002, 23 (03) : 130 - 138
[42] Effects of α-interferon on insulin-like growth factor-I, insulin-like growth factor-II and insulin-like growth factor binding protein-3 secretion by a human lung cancer cell line in vitro
P. Del Monte
C. Laurino
M. Arvigo
C. Palermo
F. Minuto
A. Barreca
Journal of Endocrinological Investigation, 2005, 28 : 432 - 439
[43] DIFFUSION OF INSULIN-LIKE GROWTH FACTOR-I IN HUMAN BREAST-CANCER EXPLANTS
HECQUET, B
PEYRAT, JP
CANCER LETTERS, 1990, 54 (1-2) : 29 - 36
[44] Insulin-like growth factor-I regulates GPER expression and function in cancer cells
De Marco, P.
Bartella, V.
Vivacqua, A.
Lappano, R.
Santolla, M. F.
Morcavallo, A.
Pezzi, V.
Belfiore, A.
Maggiolini, M.
ONCOGENE, 2013, 32 (06) : 678 - 688
[45] Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation
Tian, Dan
Mitchell, Isaiah
Kreeger, Pamela K.
BMC SYSTEMS BIOLOGY, 2016, 10
[46] Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum
Haghir, Hossein
Rezaee, Abd-Al-Rahim
Nomani, Hossein
Sankian, Mojtaba
Kheradmand, Hamed
Hami, Javad
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2013, 33 (03) : 369 - 377
[47] Effect of tamoxifen on lipoprotein(a) and insulin-like growth factor-I (IGF-I) in healthy women
Decensi, A
Robertson, C
Ballardini, B
Paggi, D
Guerrieri-Gonzaga, A
Bonanni, B
Manetti, L
Johansson, H
Barreca, A
Bettega, D
Costa, A
EUROPEAN JOURNAL OF CANCER, 1999, 35 (04) : 596 - 600
[48] Age-dependent decreases in insulin-like growth factor-I and its receptor expressions in the gerbil olfactory bulb
Lee, Tae-Kyeong
Chen, Bai Hui
Lee, Jae-Chul
Shin, Myoung Cheol
Cho, Jun Hwi
Lee, Hyang-Ah
Choi, Jung Hoon
Hwang, In Koo
Kang, Il Jun
Ahn, Ji Hyeon
Park, Joon Ha
Choi, Soo Young
Won, Moo-Ho
MOLECULAR MEDICINE REPORTS, 2018, 17 (06) : 8161 - 8166
[49] Intermittent hypoxia suppression of growth hormone and insulin-like growth factor-I in the neonatal rat liver
Cai, Charles
Ahmad, Taimur
Valencia, Gloria B.
Arand, Jacob, V
Xu, Jiliu
Beharry, Kay D.
GROWTH HORMONE & IGF RESEARCH, 2018, 41 : 54 - 63
[50] Structural organization of binding determinants in the molecule of insulin-like growth factor-I (IGF-I)
Kolychev, A. P.
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2010, 46 (01) : 87 - 112

← 1 2 3 4 5 →