The role of the insulin-like growth factor-I receptor in malignancy: An update

被引：54
|
作者：
Seccareccia, Erica [1 ]
Brodt, Pnina [1 ,2 ]
机构：
[1] McGill Univ, Dept Med, Montreal, PQ H3A 1A1, Canada
[2] McGill Univ, Dept Surg, Montreal, PQ H3A 1A1, Canada
来源：
GROWTH HORMONE & IGF RESEARCH | 2012年 / 22卷 / 06期
关键词：
IGF; Cancer stem cell; EMT; Angiogenesis; Metastasis; Targeted therapy; CANCER STEM-CELLS; TO-MESENCHYMAL TRANSITION; NF-KAPPA-B; BREAST-CANCER; FACTOR EXPRESSION; MULTIPLE-MYELOMA; PROSTATE-CANCER; AUTOCRINE LOOP; MESSENGER-RNA; ANTISENSE RNA;
D O I：
10.1016/j.ghir.2012.09.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the past three decades, evidence has been accumulating that: the ICE-I receptor/ligand system plays an important role in malignant disease. This has led to a search for specific inhibitors of the ICF receptor for cancer therapy, revealing some predictable, but also unexpected challenges. Here we review recent data that highlight the essential role of the IGF axis in several important steps in cancer cell progression and metastasis and highlight cellular processes that have been the focus of much interest and new insight in recent years. Strategies used to target the IGF axis clinically are summarized and the obstacles encountered are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：193 / 199
页数：7
相关论文
共 50 条
  • [11] The insulin-like growth factor-I receptor (IGF-IR) in breast cancer: biology and treatment strategies
    Motallebnezhad, Morteza
    Aghebati-Maleki, Leili
    Jadidi-Niaragh, Farhad
    Nickho, Hamid
    Samadi-Kafil, Hosein
    Shamsasenjan, Karim
    Yousefi, Mehdi
    TUMOR BIOLOGY, 2016, 37 (09) : 11711 - 11721
  • [12] Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation
    Yan, Xiao-Di
    Yao, Min
    Wang, Li
    Zhang, Hai-Jian
    Yan, Mei-Juan
    Gu, Xing
    Shi, Yun
    Chen, Jie
    Dong, Zhi-Zhen
    Yao, Deng-Fu
    WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (36) : 6084 - 6092
  • [13] Supramolecular Nanofibers with Superior Bioactivity to Insulin-Like Growth Factor-I
    Shang, Yuna
    Zhi, Dengke
    Feng, Guowei
    Wang, Zhongyan
    Mao, Duo
    Guo, Shuang
    Liu, Ruihua
    Liu, Lulu
    Zhang, Shuhao
    Sun, Shenghuan
    Wang, Kai
    Kong, Deling
    Gao, Jie
    Yang, Zhimou
    NANO LETTERS, 2019, 19 (03) : 1560 - 1569
  • [14] Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer's Disease
    Galle, Sara A.
    van der Spek, Ashley
    Drent, Madeleine L.
    Brugts, Michael P.
    Scherder, Erik J. A.
    Janssen, Joseph A. M. J. L.
    Ikram, M. Arfan
    van Duijn, Cornelia M.
    FRONTIERS IN AGING NEUROSCIENCE, 2019, 11
  • [15] Apigenin Attenuates Insulin-Like Growth Factor-I Signaling in an Autochthonous Mouse Prostate Cancer Model
    Sanjeev Shukla
    Gregory T. MacLennan
    Pingfu Fu
    Sanjay Gupta
    Pharmaceutical Research, 2012, 29 : 1506 - 1517
  • [16] Free insulin-like growth factor-I and breast cancer risk
    Li, BDL
    Khosravi, MJ
    Berkel, HJ
    Diamandi, A
    Dayton, MA
    Smith, M
    Yu, H
    INTERNATIONAL JOURNAL OF CANCER, 2001, 91 (05) : 736 - 739
  • [17] Targeting Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 Signaling Pathways
    Lee, Hyun
    Kim, So Ri
    Oh, Youngman
    Cho, Seong Ho
    Schleimer, Robert P.
    Lee, Yong Chul
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2014, 50 (04) : 667 - 677
  • [18] Apigenin Attenuates Insulin-Like Growth Factor-I Signaling in an Autochthonous Mouse Prostate Cancer Model
    Shukla, Sanjeev
    MacLennan, Gregory T.
    Fu, Pingfu
    Gupta, Sanjay
    PHARMACEUTICAL RESEARCH, 2012, 29 (06) : 1506 - 1517
  • [19] The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells
    Malaguarnera, Roberta
    Belfiore, Antonino
    FRONTIERS IN ENDOCRINOLOGY, 2014, 5
  • [20] Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups
    Bjorner, Sofie
    Rosendahl, Ann H.
    Simonsson, Maria
    Markkula, Andrea
    Jirstrom, Karin
    Borgquist, Signe
    Rose, Carsten
    Ingvar, Christian
    Jernstrom, Helena
    ONCOTARGET, 2017, 8 (06) : 9093 - 9107
12345