Small molecule capture and release from PEI-functionalized single walled carbon nanotubes with endoscopic ultrasound

被引：8
作者：
Dillon, Eoghan [1 ]
Bhutani, Manoop S. [2 ]
Barron, Andrew R. [1 ,3 ,4 ]
机构：
[1] Rice Univ, Dept Chem, Houston, TX 77005 USA
[2] Univ Texas Houston, MD Anderson Canc Ctr, Dept Gastroenterol, Houston, TX 77030 USA
[3] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA
[4] Swansea Univ, Coll Engn, Swansea SA2 8PP, W Glam, Wales
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2013年 / 1卷 / 10期
关键词：
ZERO-ORDER RELEASE; DRUG-DELIVERY; ETHANOL INJECTION; CARCINOMA; PANCREAS; TABLET;
D O I：
10.1039/c3tb00456b
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Water soluble polyethyleneimine functionalized single wall carbon nanotubes (PEI-SWNTs) can be loaded with the therapeutic agents acetic acid and the gemcitabine analogue, deoxycytidine (dC). The amount of loading is based on initial sonication time and the solubility of the agent. The use of an endoscopic ultrasound (EUS) results in the controlled release of the agents from the PEI-SWNT conjugate. The release of acetic acid occurs by first-order kinetics, however, the release of the majority of the dC occurs by the more desired zero-order release.
引用
收藏
页码：1461 / 1465
页数：5
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