Wnt your brain be inflamed? Yes, it Wnt!

被引：138
作者：
Marchetti, Bianca [1 ,2 ]
Pluchino, Stefano [3 ,4 ,5 ]
机构：
[1] Univ Catania, Sch Med, Pharmacol Sect, Dept Clin & Mol Biomed, I-95125 Catania, Italy
[2] OASI Inst Res & Care Mental Retardat & Brain Agin, Neuropharmacol Sect, I-94018 Troina, Italy
[3] Univ Cambridge, John van Geest Ctr Brain Repair, Dept Clin Neurosci, Cambridge CB2 0PY, England
[4] Univ Cambridge, Wellcome Trust Med Res Council Stem Cell Inst, Cambridge CB2 1QR, England
[5] Cambridge Biomed Res Ctr, Cambridge CB2 0QQ, England
来源：
TRENDS IN MOLECULAR MEDICINE | 2013年 / 19卷 / 03期
基金：
欧洲研究理事会;
关键词：
Wnt; inflammation; neurodegeneration; neuroimmune interactions; neurogenesis; neural repair; NEURAL STEM-CELLS; WNT/BETA-CATENIN; PROGENITOR CELLS; PARKINSONS-DISEASE; SIGNALING PATHWAY; ISCHEMIC-STROKE; MOUSE MODEL; INDUCED NEUROPROTECTION; TRANSCRIPTION FACTORS; ENRICHED ENVIRONMENT;
D O I：
10.1016/j.molmed.2012.12.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The roles of Wnts in neural development, synaptogenesis, and cancer are generally well characterized. Nonetheless, evidence exists that interactions between the immune and nervous systems control major brain regenerative processes ranging from physiological or pathological (reparative) regeneration to neurogenesis and synaptic plasticity. Recent studies describe deregulated Wnt-Fzd signaling in degenerative and inflammatory central nervous system (CNS) disorders, and the expression of Wnt signaling components in the immune system, and in immune-like cells of the mammalian CNS. This would suggest a likely involvement of Wnts in inflammation-driven brain damage and inflammation-directed brain repair. Here, we review how Wnts modulate neuroimmune interactions and offer a perspective on the most challenging therapeutic opportunities for those CNS diseases where injury-reactive Wnt-flavored inflammation precedes secondary neurodegeneration.
引用
收藏
页码：144 / 156
页数：13
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