Effects of dopaminergic and subthalamic stimulation on musical performance

被引：3

作者：

van Vugt, Floris T. ^{[1
,2
]}

Schuepbach, Michael ^{[3
,4
,5
]}

Altenmueller, Eckart ^{[1
]}

Bardinet, Eric ^{[6
]}

Yelnik, Jerome ^{[7
]}

Haelbig, Thomas D. ^{[3
,4
,8
,9
]}

机构：

[1] Hannover Univ Mus Drama & Media, Inst Mus Physiol & Musicians Med, Hannover, Germany

[2] Univ Lyon 1, Lyon Neurosci Res Ctr CNRS UMR 5292, INSERM U1028, F-69365 Lyon, France

[3] Univ Paris 06, Assistance Publ Hop Paris, Ctr Invest Clin CIC 9503, Dept Neurol,Inst Cerveau & Moelle Epiniere, Paris, France

[4] CHU Pitie Salpetriere, INSERM, Paris, France

[5] Univ Hosp Bern, Dept Neurol, Movement Disorders Ctr, DBS Unit, CH-3010 Bern, Switzerland

[6] Univ Pierre & Marie Curie Paris 6 UMR S975, CHU Pitie Salpetriere, Ctr NeuroImagerie Rech, Inst Cerveau & Moelle Epiniere,INSERM U975,CNRS U, Paris, France

[7] Univ Pierre & Marie Curie Paris 6 UMR S975, CHU Pitie Salpetriere, Ctr Rech Inst Cerveau & Moelle Epiniere, INSERM U975,CNRS UMR7225, Paris, France

[8] Mt Sinai Sch Med, Dept Neurol, New York, NY USA

[9] Charite Univ Med Ctr, Dept Neurol, D-13353 Berlin, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2013年 / 120卷 / 05期

关键词：

Parkinson's disease; Subthalamic nucleus; Deep brain stimulation; Dopamine; Motor control; Musical performance; DEEP-BRAIN-STIMULATION; PARKINSONS-DISEASE; NUCLEUS STIMULATION; LEVODOPA; IMPROVES; ATLAS;

D O I：

10.1007/s00702-012-0923-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although subthalamic-deep brain stimulation (STN-DBS) is an efficient treatment for Parkinson's disease (PD), its effects on fine motor functions are not clear. We present the case of a professional violinist with PD treated with STN-DBS. DBS improved musical articulation, intonation and emotional expression and worsened timing relative to a timekeeper (metronome). The same effects were found for dopaminergic treatment. These results suggest that STN-DBS, mimicking the effects of dopaminergic stimulation, improves fine-tuned motor behaviour whilst impairing timing precision.

引用

页码：755 / 759

页数：5