Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?

被引：58
作者：
Cheng, Qin [1 ,2 ]
Kyle, Dennis E. [3 ]
Gatton, Michelle L. [2 ]
机构：
[1] Australian Army Malaria Inst, Brisbane, Qld, Australia
[2] Queensland Inst Med Res, Brisbane, Qld 4006, Australia
[3] Univ S Florida, Dept Global Hlth, Tampa, FL USA
来源：
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | 2012年 / 2卷
基金：
美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会;
关键词：
Plasmodium falciparum; Artemisinin; Treatment failure; Dormancy; Artemisinin resistance; ANTIMALARIAL-DRUG-RESISTANCE; MALARIA PARASITES; IN-VITRO; TREATMENT REGIMENS; TREATMENT FAILURE; WESTERN CAMBODIA; RODENT MALARIA; ARTESUNATE; QINGHAOSU; VIVO;
D O I：
10.1016/j.ijpddr.2012.01.001
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Artemisinin (ART) based combination therapy (ACT) is used as the first line treatment of uncomplicated falciparum malaria in over 100 countries and is the cornerstone of malaria control and elimination programs in these areas. However, despite the high potency and rapid parasite killing action of ART derivatives there is a high rate of recrudescence associated with ART monotherapy and recrudescence is not uncommon even when ACT is used. Compounding this problem are reports that some parasites in Cambodia, a known foci of drug resistance, have decreased in vivo sensitivity to ART. This raises serious concerns for the development of ART resistance in the field even though no major phenotypic and genotypic changes have yet been identified in these parasites. In this article we review available data on the characteristics of ART, its effects on Plasmodium falciparum parasites and present a hypothesis to explain the high rate of recrudescence associated with this potent class of drugs and the current enigma surrounding ART resistance. (C) 2012 Australian Society for Parasitology Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：249 / 255
页数：7
相关论文
共 67 条
[1]   Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (Encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10 [J].
Afonso, A ;
Hunt, P ;
Cheesman, S ;
Alves, AC ;
Cunha, CV ;
do Rosário, V ;
Cravo, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (02) :480-489
[2]   High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia [J].
Anderson, Tim J. C. ;
Nair, Shalini ;
Nkhoma, Standwell ;
Williams, Jeff T. ;
Imwong, Mallika ;
Yi, Poravuth ;
Socheat, Duong ;
Das, Debashish ;
Chotivanich, Kesinee ;
Day, Nicholas P. J. ;
White, Nicholas J. ;
Dondorp, Arjen M. .
JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (09) :1326-1330
[3]   In vivo removal of malaria parasites from red blood cells without their destruction in acute falciparum malaria [J].
Angus, BJ ;
Chotivanich, K ;
Udomsangpetch, R ;
White, NJ .
BLOOD, 1997, 90 (05) :2037-2040
[4]  
[Anonymous], 1996, 14 INT C TROP MED MA
[5]   Artemisinin and its derivatives - An important new class of antimalarial agents [J].
Balint, GA .
PHARMACOLOGY & THERAPEUTICS, 2001, 90 (2-3) :261-265
[6]   Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites [J].
Beez, Dorothee ;
Sanchez, Cecilia P. ;
Stein, Wilfred D. ;
Lanzer, Michael .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (01) :50-55
[7]   The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin [J].
Bhisutthibhan, J ;
Pan, XQ ;
Hossler, PA ;
Walker, DJ ;
Yowell, CA ;
Carlton, J ;
Dame, JB ;
Meshnick, SR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (26) :16192-16198
[8]   Malaria associated anaemia, drug resistance and antimalarial combination therapy [J].
Björkman, A .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2002, 32 (13) :1637-1643
[9]  
Bray PG, 2005, CURR TOP MICROBIOL, V295, P3
[10]   Ex vivo perfusion of human spleens maintains clearing and processing functions [J].
Buffet, PA ;
Milon, G ;
Brousse, V ;
Correas, JM ;
Dousset, B ;
Couvelard, A ;
Kianmanesh, R ;
Farges, O ;
Sauvanet, A ;
Paye, F ;
Ungeheuer, MN ;
Ottone, C ;
Khun, H ;
Fiette, L ;
Guigon, G ;
Huerre, M ;
Mercereau-Puijalon, O ;
David, PH .
BLOOD, 2006, 107 (09) :3745-3752
1234567