Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system

被引：63
|
作者：
Coburn, J
Frank, DW
机构：
[1] Tufts Univ, New England Med Ctr, Div Rheumatol & Immunol, Boston, MA 02111 USA
[2] Med Coll Wisconsin, Dept Microbiol, Milwaukee, WI 53226 USA
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 06期
关键词：
D O I：
10.1128/IAI.67.6.3151-3154.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa, macrophages were efficiently killed by P. aeruginosa. Both responses were dependent on the type III secretion system.
引用
收藏
页码：3151 / 3154
页数：4
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