Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics

被引：149

作者：

Rodrigues, Meryl ^{[1
,2
]}

Fan, Jia ^{[1
]}

Lyon, Christopher ^{[1
]}

Wan, Meihua ^{[3
]}

Hu, Ye ^{[1
,2
]}

机构：

[1] Arizona State Univ, Biodesign Inst, Virginia G Piper Biodesign Ctr Personalized Diagn, Tempe, AZ 85287 USA

[2] Arizona State Univ, Sch Biol & Hlth Syst Engn, Tempe, AZ 85287 USA

[3] Sichuan Univ, West China Hosp, Dept Integrated Tradit Chinese & Western Med, Chengdu 610041, Sichuan, Peoples R China

来源：

THERANOSTICS | 2018年 / 8卷 / 10期

关键词：

extracellular vesicles; exosomes; pathogenesis; immune system; diagnostic; therapeutic; CELL-DERIVED EXOSOMES; HEPATITIS-C VIRUS; PEPTIDE-BASED VACCINE; HIV TYPE-1 NEF; MYCOBACTERIUM-TUBERCULOSIS; DENDRITIC CELLS; T-CELLS; ANTIGEN PRESENTATION; PROTEOMIC ANALYSIS; MEMBRANE-VESICLES;

D O I：

10.7150/thno.20576

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Extracellular vesicles (EVs), or exosomes, are nanovesicles of endocytic origin that carry host and pathogen-derived protein, nucleic acid, and lipid cargos. They are secreted by most cell types and play important roles in normal cell-to-cell communications but can also spread pathogen- and host-derived molecules during infections to alter immune responses and pathophysiological processes. New research is beginning to decipher how EVs influence viral and bacterial pathogenesis. In this review, we will describe how EVs influence viral and bacterial pathogenesis by spreading pathogen-derived factors and how they can promote and inhibit the immune response to these pathogens. We will also discuss the emerging potential of EVs as diagnostic and therapeutic tools.

引用

页码：2709 / 2721

页数：13

共 114 条

[1] B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines [J].