Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics

被引：26

作者：

Hu, Xi-Le ^{[1
,2
]}

Li, Dan ^{[3
]}

Shao, Lei ^{[3
]}

Dong, Xiaojing ^{[3
]}

He, Xiao-Peng ^{[1
,2
]}

Chen, Guo-Rong ^{[1
,2
]}

Chen, Daijie ^{[3
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

[3] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai 200040, Peoples R China

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2015年 / 6卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Triazolyl glycolipid; click reaction; beta-lactams; MRSA; superbacteria; CLICK CHEMISTRY; STAPHYLOCOCCUS-AUREUS; RESISTANCE; PENICILLIN; AZIDES;

D O I：

10.1021/acsmedchemlett.5b00142

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We show here that a series of triazolyl glycolipid derivatives modularly synthesized by a "click" reaction have the ability to increase the susceptibility of a drug-resistant bacterium to beta-lactam antibiotics. We determine that the glycolipids can suppress the minimal inhibitory concentration of a number of ineffective beta-lactams, upward of 256-fold, for methicillin-resistant Staphylococuss aureus (MRSA). The mechanism of action has been preliminarily probed and discussed.

引用

页码：793 / 797

页数：5

共 35 条

[11] pH Triggered Doxorubicin Delivery of PEGylated Glycolipid Conjugate Micelles for Tumor Targeting Therapy [J].

Hu, Fu-Qiang ;

Zhang, Yin-Ying ;

You, Jian ;

Yuan, Hong ;

Du, Yong-Zhong .

MOLECULAR PHARMACEUTICS, 2012, 9 (09) :2469-2478

[12] Mechanisms of drug combinations: interaction and network perspectives [J].

Jia, Jia ;

Zhu, Feng ;

Ma, Xiaohua ;

Cao, Zhiwei W. ;

Li, Yixue X. ;

Chen, Yu Zong .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (02) :111-128

[13] Ceftaroline fosamil: a new broad-spectrum cephalosporin [J].

Laudano, Joseph B. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 :III11-III18

[14] Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus:: Evidence for the cooperative functioning of PBP2, PBP4, and PBP2A [J].

Leski, TA ;

Tomasz, A .

JOURNAL OF BACTERIOLOGY, 2005, 187 (05) :1815-1824

[15] Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold [J].

Li, Cui ;

He, Xiao-Peng ;

Zhang, Yin-Jie ;

Li, Zhen ;

Gao, Li-Xin ;

Shi, Xiao-Xin ;

Xie, Juan ;

Li, Jia ;

Chen, Guo-Rong ;

Tang, Yun .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) :4212-4218

[16] Cu-catalyzed azide-alkyne cycloaddition [J].

Meldal, Morten ;

Tornoe, Christian Wenzel .

CHEMICAL REVIEWS, 2008, 108 (08) :2952-3015

[17] Emerging Infectious Diseases: Threats to Human Health and Global Stability [J].

Morens, David M. ;

Fauci, Anthony S. .

PLOS PATHOGENS, 2013, 9 (07)

[18] Inhibition of Influenza Virus Activity by Multivalent Glycoarchitectures with Matched Sizes [J].

Papp, Ilona ;

Sieben, Christian ;

Sisson, Adam L. ;

Kostka, Johanna ;

Boettcher, Christoph ;

Ludwig, Kai ;

Herrmann, Andreas ;

Haag, Rainer .

CHEMBIOCHEM, 2011, 12 (06) :887-895

[19] Synthesis of 1,2,3-Triazolo-Linked Octyl (1→6)-α-D-Oligomannosides and Their Evaluation in Mycobacterial Mannosyltransferase Assay [J].

Polakova, Monika ;

Belanova, Martina ;

Mikusova, Katarina ;

Lattova, Erika ;

Perreault, Helene .

BIOCONJUGATE CHEMISTRY, 2011, 22 (02) :289-298

[20]

RIORDAN JR, 1989, SCIENCE, V245, P1066

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