HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis

被引：31

作者：

Bokesch, Heidi R. ^{[1
,2
]}

Wamiru, Antony ^{[1
,2
]}

Le Grice, Stuart F. J. ^{[3
]}

Beutler, John A. ^{[1
]}

McKee, Tawnya C. ^{[1
]}

McMahon, James B. ^{[1
]}

机构：

[1] NCI, Mol Targets Dev Program, Frederick, MD 21702 USA

[2] NCI, SAIC Frederick Inc, Frederick, MD 21702 USA

[3] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/np8002518

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in vitro with IC(50) values of 1.46, > 18, and 1.19 mu M, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1(RT), none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 mu g/mL).

引用

页码：1634 / 1636

页数：3

共 16 条

[11] NMR SPECTRAL-ANALYSIS OF POLYPHENOLS FROM PUNICA-GRANATUM [J].

NAWWAR, MAM ;

HUSSEIN, SAM ;

MERFORT, I .

PHYTOCHEMISTRY, 1994, 36 (03) :793-798

[12] A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity [J].

Parniak, MA ;

Min, KL ;

Budihas, SR ;

Le Grice, SFJ ;

Beutler, JA .

ANALYTICAL BIOCHEMISTRY, 2003, 322 (01) :33-39

[13] An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis [J].

Takada, Kentaro ;

Bermingham, Alun ;

O'Keefe, Barry R. ;

Wamiru, Antony ;

Beutler, John A. ;

Le Grice, Stuart F. J. ;

Lloyd, John ;

Gustafson, Kirk R. ;

McMahon, James B. .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (10) :1647-1649

[14] Anti-oxidant constituents from Sedum takesimense [J].

Thuong, Phuong Thien ;

Ho, Jeong Kang ;

MinKyun, Na ;

Wenyi, Jin ;

Ui, Jung Youn ;

Yeon, Hee Seong ;

Kyung-Sik, Song ;

Byung-Sun, Min ;

Bae, KiHwan .

PHYTOCHEMISTRY, 2007, 68 (19) :2432-2438

[15]

Wiedenfeld MH, 2007, SCI PHARM, V75, P29

[16] CHEMOTAXONOMIC STUDIES OF SAXIFRAGACEAE .3. ELLAGITANNINS FROM TELLIMA-GRANDIFLORA [J].

WILKINS, CK ;

BOHM, BA .

PHYTOCHEMISTRY, 1976, 15 (01) :211-214

← 1 2 →