HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis

被引：31

作者：

Bokesch, Heidi R. ^{[1
,2
]}

Wamiru, Antony ^{[1
,2
]}

Le Grice, Stuart F. J. ^{[3
]}

Beutler, John A. ^{[1
]}

McKee, Tawnya C. ^{[1
]}

McMahon, James B. ^{[1
]}

机构：

[1] NCI, Mol Targets Dev Program, Frederick, MD 21702 USA

[2] NCI, SAIC Frederick Inc, Frederick, MD 21702 USA

[3] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/np8002518

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in vitro with IC(50) values of 1.46, > 18, and 1.19 mu M, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1(RT), none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 mu g/mL).

引用

页码：1634 / 1636

页数：3

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