Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors

被引:8
作者
Onul, Nihal [1 ]
Ertik, Onur [2 ]
Mermer, Nese [1 ]
Yanardag, Refiye [2 ]
机构
[1] Istanbul Univ, Organ Chem Div, Dept Chem, Fac Engn, TR-34320 Istanbul, Turkey
[2] Istanbul Univ, Biochem Div, Dept Chem, Fac Engn, TR-34320 Istanbul, Turkey
关键词
HEPATITIS-C VIRUS; ALLYL MERCAPTAN; POLYHALOGENATED NITROBUTADIENES; ANTIMICROBIAL PROPERTIES; CHOLESTEROL-SYNTHESIS; IN-VITRO; DERIVATIVES; DESIGN; ACID; PYRIDAZINES;
D O I
10.1155/2018/4386031
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
S-substituted perhalo-2-nitrobuta-1,3-dienes 3a, b were synthesized by the reaction of polyhalo-2-nitrobuta-1,3-dienes 1a, b with allyl mercaptan. 1-(2,3-Dibromopropanethio)-4-bromo-1,3,4-trichloro-2-nitrobuta-1,3-diene 4 was obtained from the addition of bromine to S-substituted polyhalo-2-nitrobuta-1,3-diene 3b in carbon tetrachloride. Sulfoxides 5a, b, and 6 were obtained from the reaction of thiosubstituted polyhalonitrobutadienes 3a, b, and 4 with m-CPBA in CHCl3. The structures of the new compounds were determined by spectroscopic data (FTIR, H-1 NMR, C-13 NMR, MS). These compounds exhibited antixanthine oxidase, antityrosinase, antielastase, and antineuraminidase activities.
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页数:11
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