Pyloricidins, novel anti-Helicobacter pylori antibiotics produced by Bacillus sp.: I.: Taxonomy, fermentation and biological activity

被引：14
作者：
Nakao, M
Miyagawa, K
Nakano, Y
Sakane, T
Tada, M
Nishimura, O
Fujino, M
机构：
[1] Takeda Chem Ind Ltd, Div Pharmaceut Res, Pharmaceut Discovery Ctr, Yodogawa Ku, Osaka 5328686, Japan
[2] Takeda Chem Ind Ltd, Div Pharmaceut Res, Pharmacol Res Labs 2, Yodogawa Ku, Osaka 5328686, Japan
[3] Takeda Chem Ind Ltd, Div Pharmaceut Res, Tsukuba, Ibaraki 3004293, Japan
[4] Takeda Chem Ind Ltd, Chuo Ku, Osaka 5408645, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 11期
关键词：
D O I：
10.7164/antibiotics.54.926
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A(1), A(2), B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori infection as a single agent.
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页码：926 / 933
页数：8
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