Contraception for Men: A Breakthrough New Approach

被引：9

作者：

Bremner, William J. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

CELL | 2012年 / 150卷 / 04期

关键词：

1ST BROMODOMAIN; SPERMATOGENESIS; INHIBITION; BRDT;

D O I：

10.1016/j.cell.2012.07.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There has not been a new reversible contraceptive for men since the development of the condom, centuries ago. Matzuk et al. describe a new molecular approach using administration of a small molecule to directly and reversibly inhibit spermatogenesis in mice by blocking the function of a testicular bromodomain without apparent adverse effect on the organism or offspring.

引用

页码：667 / 668

页数：2

共 9 条

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