Permeation of biological compounds through porous poly(L-lactic acid) (PLLA) microtube array membranes (MTAMs)

被引：18
|
作者：
Hung, Wei-Chiang [1 ]
Lin, Lin-Hong [1 ]
Tsen, Wen-Chin [2 ]
Shie, Han-Shian [3 ]
Chiu, Hsien-Lung [4 ]
Yang, Thomas C. K. [4 ]
Chen, Chien-Chung [3 ,5 ]
机构：
[1] Taipei Med Univ, Dept Dent, Taipei 11052, Taiwan
[2] LEE MING Inst Technol, Dept Fash & Design, Taipei, Taiwan
[3] Taipei Med Univ, Grad Inst Biomed Mat & Tissue Engn, Taipei 11052, Taiwan
[4] Natl Taipei Univ Technol, Dept Mat Sci & Engn, Taipei 10608, Taiwan
[5] Taipei Med Univ, Ctr Biomed Implants & Microsurg Devices, Taipei 11052, Taiwan
来源：
EUROPEAN POLYMER JOURNAL | 2015年 / 67卷
关键词：
Permeation; Porous microtube array membrane (p-MTAM); Electrospinning; Poly((L)-lactic acid) PLLA; Nerve guide conduit (NGC); Nerve regeneration; PERIPHERAL-NERVE REGENERATION; REPAIR; GUIDE; IMPLANTATION; SCAFFOLDS; CONDUITS; SURFACE; GROWTH; INJURY; CELLS;
D O I：
10.1016/j.eurpolymj.2015.03.055
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this study, the permeation of two biological compounds through a novel porous poly(L-lactic acid) (PLLA) microtube array membrane (MTAM) were investigated. Glucose and bovine serum albumin (BSA) were permeated through PLEA MTAMs to simulate the transportation of biological compounds during nerve regeneration. PLEA MTAMs with various porous wall structures were prepared by the addition of porogen. Electrospinning process was conducted to produce solid MTAMs. Porous MTAMs were obtained by washing off the porogen. Permeation of BSA and glucose were investigated by utilizing a home-made permeation unit at 37 degrees C for both inflow and outflow. The permeation rate increased with the porosity of the MTAM; with the inflow rate faster than the outflow rate for both compounds suggesting a diffusive permeation. The rate of BSA permeation was faster than that of glucose, Fourier transfer infra-red (FTIR) spectra of the two compounds permeated through PLEA membranes were obtained to elucidate this phenomena. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：166 / 173
页数：8
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