Anti-cancer natural products isolated from chinese medicinal herbs

被引：270

作者：

Tan, Wen ^{[1
,2
]}

Lu, Jinjian ^{[1
,2
,3
]}

Huang, Mingqing ^{[1
,2
,4
]}

Li, Yingbo ^{[1
,2
]}

Chen, Meiwan ^{[1
,2
]}

Wu, Guosheng ^{[1
,2
]}

Gong, Jian ^{[1
,2
]}

Zhong, Zhangfeng ^{[1
,2
]}

Xu, Zengtao ^{[1
,2
]}

Dang, Yuanye ^{[1
,2
]}

Guo, Jiajie ^{[1
,2
]}

Chen, Xiuping ^{[1
,2
]}

Wang, Yitao ^{[1
,2
]}

机构：

[1] Univ Macau, State Key Lab Qual Res Chinese Med, Taipa, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, Taipa, Peoples R China

[3] Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Zhejiang, Peoples R China

[4] Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou 350108, Fujian, Peoples R China

来源：

CHINESE MEDICINE | 2011年 / 6卷

关键词：

NF-KAPPA-B; SIGNAL-REGULATED KINASE; CELL-CYCLE ARREST; HUMAN BREAST-CANCER; DIHYDROARTEMISININ INDUCES APOPTOSIS; ORIDONIN-INDUCED APOPTOSIS; MURINE FIBROSARCOMA L929; BERBERINE-INDUCED APOPTOSIS; ETOPOSIDE-INDUCED APOPTOSIS; GROWTH-FACTOR EXPRESSION;

D O I：

10.1186/1749-8546-6-27

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in vivo. This article summarizes recent advances in in vitro and in vivo research on the anti-cancer effects and related mechanisms of some promising natural products. These natural products are also reviewed for their therapeutic potentials, including flavonoids (gambogic acid, curcumin, wogonin and silibinin), alkaloids (berberine), terpenes (artemisinin, beta-elemene, oridonin, triptolide, and ursolic acid), quinones (shikonin and emodin) and saponins (ginsenoside Rg(3)), which are isolated from Chinese medicinal herbs. In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed.

引用

页数：15

共 236 条

[1] Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells [J].