Neonatal intestinal dysbiosis

被引：55

作者：

Underwood, Mark A. ^{[1
]}

Mukhopadhyay, Sagori ^{[2
]}

Lakshminrusimha, Satyan ^{[1
]}

Bevins, Charles L. ^{[3
]}

机构：

[1] Univ Calif Davis, Sch Med, Dept Pediat, Sacramento, CA 95817 USA

[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA USA

来源：

JOURNAL OF PERINATOLOGY | 2020年 / 40卷 / 11期

基金：

美国国家卫生研究院;

关键词：

HUMAN GUT MICROBIOME; NECROTIZING ENTEROCOLITIS; PRETERM INFANTS; PATTERNED PROGRESSION; EARLY-LIFE; PROBIOTICS; ASSOCIATIONS; METAANALYSIS; CHILDHOOD; EXPOSURE;

D O I：

10.1038/s41372-020-00829-2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The initial colonization of the neonatal intestinal tract is influenced by delivery mode, feeding, the maternal microbiota, and a host of environmental factors. After birth, the composition of the infant's microbiota undergoes a series of significant changes particularly in the first weeks and months of life ultimately developing into a more stable and diverse adult-like population in childhood. Intestinal dysbiosis is an alteration in the intestinal microbiota associated with disease and appears to be common in neonates. The consequences of intestinal dysbiosis are uncertain, but strong circumstantial evidence and limited confirmations of causality suggest that dysbiosis early in life can influence the health of the infant acutely, as well as contribute to disease susceptibility later in life.

引用

页码：1597 / 1608

页数：12

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