Serum and adipose tissue as matrices for assessment of exposure to persistent organic pollutants in breast cancer patients

被引:54
作者
Artacho-Cordon, F. [1 ,3 ]
Fernandez-Rodriguez, M. [1 ,3 ]
Garde, C. [1 ]
Salamanca, E. [1 ,3 ]
Iribarne-Duran, L. M. [1 ,3 ]
Torne, P. [1 ]
Exposito, J. [1 ,2 ]
Papay-Ramirez, L. [1 ]
Fernandez, M. F. [1 ,3 ,4 ]
Olea, N. [1 ,3 ,4 ]
Arrebola, J. P. [1 ,2 ,3 ,4 ]
机构
[1] Hosp Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain
[2] Virgen de las Nieves Univ Hosp, Dept Radiat Oncol, Granada, Spain
[3] Univ Granada, Radiol & Phys Med Dept, E-18071 Granada, Spain
[4] CIBERESP, Barcelona, Spain
关键词
Organochlorine pesticides; Polychlorinated biphenyls; Adipose tissue; Serum; Breast cancer; EFFECTIVE XENOESTROGEN BURDEN; POLYCHLORINATED-BIPHENYLS; ORGANOCHLORINE PESTICIDES; ADULT COHORT; PERFLUORINATED COMPOUNDS; ESTROGEN-RECEPTOR; GREENLANDIC INUIT; DANISH WOMEN; BLOOD-LEVELS; RISK;
D O I
10.1016/j.envres.2015.08.020
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The aim of this study was to assess differences between two biological matrices (serum and breast adipose tissue) in the evaluation of persistent organic pollutant (POP) exposure in breast cancer patients. The study population consisted of 103 women undergoing surgery for newly diagnosed breast carcinoma in a public hospital in Granada, Southern Spain. Independent variables were gathered from questionnaires and clinical records. POP concentrations were quantified in breast adipose tissue and serum samples. Spearman correlation tests were performed between pairs of POP concentrations and stepwise multivariable linear regression analyses were conducted to assess predictors of concentrations in the two matrices. p,p'- Dichlorodiphenyldichloroethylene (p,p'-DDE) showed the the highest median concentration in both matrices (194.34 and 173.84 ng/g lipid in adipose tissue and serum, respectively). Median wet-basis adipose tissue:serum ratios ranged from 109.34 to 651.62, while lipid-basis ratios ranged from 0.88 to 4.34. In general, we found significant positive correlation coefficients between pairs of POPs in adipose tissue and in serum, which were always higher in adipose tissue. We found positive and statistically significant correlations between serum and adipose tissue concentrations of p,p'-DDE and hexachlorobenzene (HCB) but not of polychlorinated biphenyls (PCBs). Age was positively associated with most POPs in adipose tissue and serum, while the body mass index was positively associated with adipose tissue HCB concentrations and negatively associated with serum PCB-153 and PCB-138 concentrations. Recent weight loss was inversely associated with POP residues in adipose tissue and positively associated with POP residues in serum. Serum HCB and PCB-180 concentrations were lower in patients who had received preoperative chemotherapy. According to our results, serum and adipose tissue POP concentrations in breast cancer patients may be differentially affected by external predictors. Taken together, these findings indicate the need to take account of the individual POP(s) under study and the biological matrix used when relating internal POP exposure to breast cancer disease and to make a careful selection of covariates for adjusting the model. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:633 / 643
页数:11
相关论文
共 80 条
[1]   Polychlorinated biphenyls in Spanish adults: Determinants of serum concentrations [J].
Agudo, Antonio ;
Goni, Fernando ;
Etxeandia, Arsenio ;
Vives, Asuncion ;
Millan, Esmeralda ;
Lopez, Raul ;
Amiano, Pilar ;
Ardanaz, Eva ;
Barricarte, Aurelio ;
Dolores Chirlaque, M. ;
Dorronsoro, Miren ;
Jakszyn, Paula ;
Larranaga, Nerea ;
Martinez, Carmen ;
Navarro, Carmen ;
Rodriguez, Laudina ;
Jose Sanchez, M. ;
Jose Tormo, M. ;
Gonzalez, Carlos A. .
ENVIRONMENTAL RESEARCH, 2009, 109 (05) :620-628
[2]   ORGANOCHLORINE COMPOUNDS IN RELATION TO BREAST-CANCER, ENDOMETRIAL CANCER, AND ENDOMETRIOSIS - AN ASSESSMENT OF THE BIOLOGICAL AND EPIDEMIOLOGIC EVIDENCE [J].
AHLBORG, UG ;
LIPWORTH, L ;
TITUSERNSTOFF, L ;
HSIEH, CC ;
HANBERG, A ;
BARON, J ;
TRICHOPOULOS, D ;
ADAMI, HO .
CRITICAL REVIEWS IN TOXICOLOGY, 1995, 25 (06) :463-531
[3]   Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro [J].
Andersen, HR ;
Vinggaard, AM ;
Rasmussen, TH ;
Gjermandsen, IM ;
Bonefeld-Jorgensen, EC .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2002, 179 (01) :1-12
[4]   Evaluation of statistical treatments of left-censored environmental data using coincident uncensored data sets: I. Summary statistics [J].
Antweiler, Ronald C. ;
Taylor, Howard E. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (10) :3732-3738
[5]  
ArchibequeEngle SL, 1997, J TOXICOL ENV HEALTH, V52, P285, DOI 10.1080/009841097159584
[6]  
Aronson KJ, 2000, CANCER EPIDEM BIOMAR, V9, P55
[7]   Factors influencing combined exposure to three indicator polychlorinated biphenyls in an adult cohort from Bolivia [J].
Arrebola, J. P. ;
Mutch, E. ;
Cuellar, M. ;
Quevedo, M. ;
Claure, E. ;
Mejia, L. M. ;
Fernandez-Rodriguez, M. ;
Freire, C. ;
Olea, N. ;
Mercado, L. A. .
ENVIRONMENTAL RESEARCH, 2012, 116 :17-25
[8]   Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and adipose tissue from Bolivia [J].
Arrebola, J. P. ;
Cuellar, M. ;
Claure, E. ;
Quevedo, M. ;
Antelo, S. R. ;
Mutch, E. ;
Ramirez, E. ;
Fernandez, M. F. ;
Olea, N. ;
Mercado, L. A. .
ENVIRONMENTAL RESEARCH, 2012, 112 :40-47
[9]   Contribution of sociodemographic characteristics, occupation, diet and lifestyle to DDT and DDE concentrations in serum and adipose tissue from a Bolivian cohort [J].
Arrebola, J. P. ;
Mutch, E. ;
Rivero, M. ;
Choque, A. ;
Silvestre, S. ;
Olea, N. ;
Ocana-Riola, R. ;
Mercado, L. A. .
ENVIRONMENT INTERNATIONAL, 2012, 38 (01) :54-61
[10]   Predictors of concentrations of hexachlorobenzene in human adipose tissue: A multivariate analysis by gender in Southern Spain [J].
Arrebola, J. P. ;
Martin-Olmedo, P. ;
Fernandez, M. F. ;
Sanchez-Cantalejo, E. ;
Jimenez-Rios, J. A. ;
Torne, P. ;
Porta, M. ;
Olea, N. .
ENVIRONMENT INTERNATIONAL, 2009, 35 (01) :27-32