In vivo antibacterial property of Ti-Cu sintered alloy implant

被引：64
作者：
Wang, Xiaoyan [1 ]
Dong, Hui [2 ]
Liu, Jie [3 ]
Qin, Gaowu [1 ]
Chen, Dafu [4 ]
Zhang, Erlin [1 ]
机构：
[1] Northeastern Univ, Educ Minist China, Key Lab Anisotropy & Texture Mat, Sch Met,Sch Mat Sci & Engn, Shenyang 110819, Liaoning, Peoples R China
[2] Qiqihar Med Univ, Affiliated Hosp 3, Qiqihar 161001, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, Dept Prosthodont, Qingdao 266003, Shandong, Peoples R China
[4] Beijing Jishuitan Hosp, Beijing Res Inst Orthopaed & Traumatol, Beijing Lab Biomed Mat, Lab Bone Tissue Engn, Beijing 100035, Peoples R China
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 100卷
基金：
中国国家自然科学基金;
关键词：
In vivo; Antibacterial properties; Ti-10Cu alloy; MECHANICAL-PROPERTIES; CORROSION-RESISTANCE; OSTEOBLAST FUNCTIONS; ION-IMPLANTATION; TITANIUM; SURFACE; COPPER; VITRO; BIOCOMPATIBILITY; MICROSTRUCTURE;
D O I：
10.1016/j.msec.2019.02.084
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In-vivo antibacterial property of Ti-10Cu sintered alloy was investigated in comparison with pure titanium (cpTi) by implanting the alloys with S. aureus suspension in the muscles of rabbits. The general appearance, the white blood cell (WBC) number, the bacteria number were checked and the pathological examination were analyzed. It has been shown that serious inflammation at day 4 and fester at day 14 were observed after implantation in ep-Ti group while only mild infection was observed at day 4 in the case of Ti-10Cu implants. Bacterial incubation results have also shown that lots of S. aureus were found in cp-Ti group at all intervals while only several bacteria at day 1 and day 4 and no bacteria after 7 days postimplantation can be found in Ti-10Cu group. All these results demonstrate the strong in vivo antibacterial property of Ti-10Cu alloy. The strong antibacterial property suggests that Ti-10Cu alloy might have potential application in orthopedic surgery and dental implant to reduce the implant-related infection or inflammation.
引用
收藏
页码：38 / 47
页数：10
相关论文
共 50 条
  • [1] [Anonymous], THESIS
  • [2] Biocompatibility of antibacterial Ti-Cu sintered alloy: in vivo bone response
    Bai, Bing
    Zhang, Erlin
    Dong, Hui
    Liu, Jie
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2015, 26 (12)
  • [3] Functionally graded hydroxyapatite coatings doped with antibacterial components
    Bai, Xiao
    More, Karren
    Rouleau, Christopher M.
    Rabiei, Afsaneh
    [J]. ACTA BIOMATERIALIA, 2010, 6 (06) : 2264 - 2273
  • [4] Multifunctional implant coatings providing possibilities for fast antibiotics loading with subsequent slow release
    Brohede, Ulrika
    Forsgren, Johan
    Roos, Stefan
    Mihranyan, Albert
    Engqvist, Hakan
    Stromme, Maria
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2009, 20 (09) : 1859 - 1867
  • [5] Antibacterial effect of 317L stainless steel contained copper in prevention of implant-related infection in vitro and in vivo
    Chai, Hongwei
    Guo, Lei
    Wang, Xiantao
    Fu, Yuping
    Guan, Junlin
    Tan, Lili
    Ren, Ling
    Yang, Ke
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2011, 22 (11) : 2525 - 2535
  • [6] Chen SH, 2004, ACTA METALL SIN, V40, P314
  • [7] In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating
    Chen, W.
    Liu, Y.
    Courtney, H. S.
    Bettenga, M.
    Agrawal, C. M.
    Bumgardner, J. D.
    Ong, J. L.
    [J]. BIOMATERIALS, 2006, 27 (32) : 5512 - 5517
  • [8] Antibacterial properties of vacuum plasma sprayed titanium coatings after chemical treatment
    Chen, Yikai
    Zheng, Xuebin
    Xie, Youtao
    Ji, Heng
    Ding, Chuanxian
    [J]. SURFACE & COATINGS TECHNOLOGY, 2009, 204 (05) : 685 - 690
  • [9] Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion
    Chua, Poh-Hui
    Neoh, Koon-Gee
    Kang, En-Tang
    Wang, Wilson
    [J]. BIOMATERIALS, 2008, 29 (10) : 1412 - 1421
  • [10] MICROBIAL BIOFILMS
    COSTERTON, JW
    LEWANDOWSKI, Z
    CALDWELL, DE
    KORBER, DR
    LAPPINSCOTT, HM
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, 1995, 49 : 711 - 745
12345